Results 1 to 10 of about 2,657 (63)
Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment [PDF]
Cancer Innovation, Volume 4, Issue 5, October 2025.Extrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in cancer research due to their roles in gene amplification, genetic heterogeneity, and drug resistance.
Hexin Li +3 more
wiley +2 more sources
Cancer: From a Genetic Disorder to a Systemic Disease [PDF]
Adv Sci (Weinh)Advanced Science, Volume 12, Issue 42, November 13, 2025.
Ada Hang‐Heng Wong, Yuming Hu
wiley +2 more sources
Research Advances of Extrachromosomal Circular DNA in Breast Cancer [PDF]
Cancer Medicine, Volume 14, Issue 19, October 2025.ABSTRACT Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer. As a distinct form of DNA, ecDNA is critically involved in the initiation, progression, diagnosis, and treatment of breast cancer.
Xiaodan Zhu +6 more
wiley +2 more sources
Centromeric Sequences in Ogataea polymorpha Genome Enable Development of Stable Multigene Expression Plasmid Tools [PDF]
Microbial Biotechnology, Volume 18, Issue 11, November 2025.The centromeric sequences of Ogataea polymorpha, a methylotrophic non‐conventional yeast, were characterised for the first time and support the development of new genetically stable centromeric plasmids with high genetic stability and compatibility, providing powerful genetic toolboxes for the synthetic biology and metabolic engineering‐driven ...
Yanfei Cheng +5 more
wiley +2 more sources
EccDNA Analysis Provides Novel Insights Into the Molecular Mechanism of Firmness of Fish Fillet [PDF]
Food Science &Nutrition, Volume 13, Issue 5, May 2025.We provide a new and basic eccDNA database for the molecular regulation of muscle firmness in grass carp. The eccDNA abundance in crisp grass carp was significantly higher than that in ordinary grass carp. EccDNAs likely play important roles in the muscle‐hardening of crisp grass carp.
Kai Zhang +8 more
wiley +2 more sources
Causes and consequences of bacterial local adaptation via MGEs in the plant microbiome
New Phytologist, Volume 249, Issue 5, Page 2215-2223, March 2026.Summary Adaptations that enable plant‐associated bacteria to fill disparate niches comprise a critical component of microbial diversity. Genes that confer locally adaptive bacterial traits, ranging from heavy metal resistance to pathogen or symbiont infectivity, often reside within mobile genetic elements (MGEs) that can move between genomes.
Stephanie Porter +3 more
wiley +1 more source
Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture
Reviews in Aquaculture, Volume 18, Issue 1, January 2026.The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos +7 more
wiley +1 more source
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions
MedComm, Volume 6, Issue 12, December 2025.Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun +7 more
wiley +1 more source
Plant Pathology, Volume 74, Issue 9, Page 2670-2681, December 2025.Dynamic plasmid copy numbers in the bacterial pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens influence disease expression in mung beans. ABSTRACT In bacteria, plasmids can confer the ability to cause disease. Although they can potentially vary in copy number, little has been reported on the dynamics of plasmids in plant‐pathogenic bacteria ...
Ahmed Saad +5 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 11, Page 2999-3002, November 2025.Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley +1 more source