Results 1 to 10 of about 87 (81)

Inheritance of extrachromosomal rDNA in Physarum polycephalum. [PDF]

Molecular and Cellular Biology, 1983
In the acellular slime mold Physarum polycephalum, the several hundred genes coding for rRNA are located on linear extrachromosomal DNA molecules of a discrete size, 60 kilobases. Each molecule contains two genes that are arranged in a palindromic fashion and separated by a central spacer region. We investigated how rDNA is inherited after meiosis. Two
C L Truitt, V M Vogt, P J Ferris
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EXPERIMENTAL ANALYSIS OF A PATERNALLY INHERITED EXTRACHROMOSOMAL FACTOR [PDF]

Genetics, 1986
ABSTRACT Virtually all known cases of extrachromosomal inheritance involve cytoplasmic inheritance through the maternal line. Recently, a paternally transmitted factor that causes the production of all-male families has been discovered in a parasitic wasp.
Johannes van den Assem, John H. Werren
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Reciprocal extrachromosomal inheritance in rye (Secale cereale L.) [PDF]

Hereditas, 2009
In an inbred line of Steel rye (Stalrag), a chlorophyll mutant (status paralbomaculatus) arose spontaneously that displayed both extrachromosomal maternal and paternal inheritance in crosses. Striata plants gave rise to albino, striata, and normal offspring when selfed.
Sune Fröst, Curt Carlbom, Ludvigs Vaivars   +2 more
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EXTRACHROMOSOMAL INHERITANCE OF CARBON DIOXIDE SENSITIVITY IN THE MOSQUITO CULEX QUINQUEFASCIATUS [PDF]

Genetics, 1983
ABSTRACT Mosquitoes from a laboratory colony of Culex quinquefasciatus from Matsu Island, China, develop irreversible paralytic symptoms after exposure to carbon dioxide at 1°. This CO2 sensitivity is caused by an inherited infectious agent, probably a virus.
Donald A. Shroyer, Leon Rosen
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Coordinated inheritance of extrachromosomal DNA species in human cancer cells

, 2023
ABSTRACTThe chromosomal theory of inheritance has dominated human genetics, including cancer genetics. Genes on the same chromosome segregate together while genes on different chromosomes assort independently, providing a fundamental tenet of Mendelian inheritance.
King L. Hung, Matthew G. Jones, Ivy Tsz-Lo Wong, Joshua T. Lange, Jens Luebeck, Elisa Scanu, Britney Jiayu He, Lotte Brückner, Rui Li, Rocío Chamorro González, Rachel Schmargon, Jan R. Dörr, Julia A. Belk, Vineet Bafna, Benjamin Werner, Weini Huang, Anton G. Henssen, Paul S. Mischel, Howard Y. Chang   +18 more
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Extrachromosomal elements in a super-suppression system of yeast I. A nuclear gene controlling the inheritance of the extrachromosomal elements [PDF]

Heredity, 1971
Extrachromosomal elements in a super-suppression system of yeast I.
B S Cox, C S H Young
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Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma [PDF]

Nature Genetics, 2016
ABSTRACTTo understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response to therapy, which is characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopic xenograft models derived from them.
Roel G.W. Verhaak, David Cherba, Sahil Seth, Julie Koeman, Emanuel F. Petricoin, Jianhua Zhang, Michelle Madden Felicella, Mary E. Winn, Siyuan Zheng, Lynda Chin, Yongying Jiang, Claudius Mueller, Asha S. Multani, Do Hyun Nam, Do Hyun Nam, Ana C. deCarvalho, Alexei Protopopov, Laila M. Poisson, Hoon Kim, Tom Mikkelsen   +19 more
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hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, EarlyView.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Nature
AbstractThe chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell ...
King L. Hung, Matthew G. Jones, Ivy Tsz-Lo Wong, Ellis J. Curtis, Joshua T. Lange, Britney Jiayu He, Jens Luebeck, Rachel Schmargon, Elisa Scanu, Lotte Brückner, Xiaowei Yan, Rui Li, Aditi Gnanasekar, Rocío Chamorro González, Julia A. Belk, Zhonglin Liu, Bruno Melillo, Vineet Bafna, Jan R. Dörr, Benjamin Werner, Weini Huang, Benjamin F. Cravatt, Anton G. Henssen, Paul S. Mischel, Howard Y. Chang   +24 more
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