Results 1 to 10 of about 2,768 (134)

Coordinated inheritance of extrachromosomal DNAs in cancer cells. [PDF]

Nature
AbstractThe chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell ...
Hung KL, Jones MG, Wong IT, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R, Scanu E, Brückner L, Yan X, Li R, Gnanasekar A, Chamorro González R, Belk JA, Liu Z, Melillo B, Bafna V, Dörr JR, Werner B, Huang W, Cravatt BF, Henssen AG, Mischel PS, Chang HY.   +24 more
europepmc   +5 more sources

Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment. [PDF]

Cancer Innov
Extrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in cancer research due to their roles in gene amplification, genetic heterogeneity, and drug resistance.
Li H, Cai J, Zhao G, Zou L.
europepmc   +2 more sources

Cancer: From a Genetic Disorder to a Systemic Disease. [PDF]

Adv Sci (Weinh)
Advanced Science, Volume 12, Issue 42, November 13, 2025.
Wong AH, Hu Y.
europepmc   +2 more sources

Research Advances of Extrachromosomal Circular DNA in Breast Cancer. [PDF]

Cancer Med
ABSTRACT Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer. As a distinct form of DNA, ecDNA is critically involved in the initiation, progression, diagnosis, and treatment of breast cancer.
Zhu X, Qian Y, Tang Q, Li J, Geng Y, Gong S, Jin C.   +6 more
europepmc   +2 more sources

Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis. [PDF]

PLoS Pathogens
Integrative and conjugative elements (ICEs) play a vital role in bacterial evolution by carrying essential genes that confer adaptive functions to the host.
Qibing Gu, Xiayu Zhu, Yong Yu, Tao Jiang, Zihao Pan, Jiale Ma, Huochun Yao   +6 more
doaj   +2 more sources

Centromeric Sequences in Ogataea polymorpha Genome Enable Development of Stable Multigene Expression Plasmid Tools. [PDF]

Microb Biotechnol
The centromeric sequences of Ogataea polymorpha, a methylotrophic non‐conventional yeast, were characterised for the first time and support the development of new genetically stable centromeric plasmids with high genetic stability and compatibility, providing powerful genetic toolboxes for the synthetic biology and metabolic engineering‐driven ...
Cheng Y, Shi Y, Sun N, Zhang X, Sun M, He X.   +5 more
europepmc   +2 more sources

EccDNA Analysis Provides Novel Insights Into the Molecular Mechanism of Firmness of Fish Fillet. [PDF]

Food Sci Nutr
We provide a new and basic eccDNA database for the molecular regulation of muscle firmness in grass carp. The eccDNA abundance in crisp grass carp was significantly higher than that in ordinary grass carp. EccDNAs likely play important roles in the muscle‐hardening of crisp grass carp.
Zhang K, Chen J, He H, Duan B, You C, Hu Z, Cai L, Xiang X, Liang R.   +8 more
europepmc   +2 more sources

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data

Oncogenesis, 2023
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance.
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang   +4 more
doaj   +1 more source

PlasmidHostFinder: Prediction of Plasmid Hosts Using Random Forest

mSystems, 2022
Plasmids play a major role facilitating the spread of antimicrobial resistance between bacteria. Understanding the host range and dissemination trajectories of plasmids is critical for surveillance and prevention of antimicrobial resistance ...
Derya Aytan-Aktug, Philip T. L. C. Clausen, Judit Szarvas, Patrick Munk, Saria Otani, Marcus Nguyen, James J. Davis, Ole Lund, Frank M. Aarestrup   +8 more
doaj   +1 more source

EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA

iScience, 2019
Summary: Oncogene amplification is one of the most common drivers of genetic events in cancer, potently promoting tumor development, growth, and progression.
Utkrisht Rajkumar, Kristen Turner, Jens Luebeck, Viraj Deshpande, Manmohan Chandraker, Paul Mischel, Vineet Bafna   +6 more
doaj   +1 more source