Results 11 to 20 of about 2,657 (63)
hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan
Aging Cell, Volume 24, Issue 8, August 2025.In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam +15 more
wiley +1 more source
EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Advanced Science, Volume 12, Issue 25, July 3, 2025.Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi +12 more
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Therapies for Mitochondrial Disease: Past, Present, and Future
Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.ABSTRACT Mitochondrial disease is a diverse group of clinically and genetically complex disorders caused by pathogenic variants in nuclear or mitochondrial DNA‐encoded genes that disrupt mitochondrial energy production or other important mitochondrial pathways. Mitochondrial disease can present with a wide spectrum of clinical features and can often be
Megan Ball +5 more
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Advanced Science, Volume 12, Issue 21, June 5, 2025.Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen +12 more
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Congcong Tian, Haiyun Gan
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Cas9‐Rep fusion tethers donor DNA in vivo and boosts the efficiency of HDR‐mediated genome editing
Plant Biotechnology Journal, Volume 23, Issue 6, Page 2006-2017, June 2025.Summary Genome editing based on the homology‐directed repair (HDR) pathway enables scar‐free and precise genetic manipulations. However, the low frequency of HDR hinders its application in plant genome editing. In this study, we engineered the fusion of Cas9 and a viral replication protein (Rep) as a molecular bridge to tether donor DNA in vivo, which ...
Zhentao Zhou +7 more
wiley +1 more source
Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes
BioEssays, Volume 47, Issue 4, April 2025.Genetic variation within the multi‐copy, multi‐locus ribosomal DNA (rDNA) can contribute to human complex trait variability. This variation takes the form of copy number, structural arrangement, and sequence differences. This review summarizes what is currently known about human rDNA variation, its causes, and its association with phenotypic outcomes ...
Francisco Rodriguez‐Algarra +3 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 9, Issue S1, June 2025.
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Extrachromosomal circular DNA are functional, heritable units that expand genomic plasticity and confer resilience. [PDF]
Front Plant SciMacGregor DR, Saski CA.
europepmc +1 more source