Results 21 to 30 of about 2,768 (134)

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

eLife, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Grant A King, Jay S Goodman, Jennifer G Schick, Keerthana Chetlapalli, Danielle M Jorgens, Kent L McDonald, Elçin Ünal   +6 more
doaj   +1 more source

Yersinia pestis pathogenicity

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Yersinia pestis belongs to those pathogenic bacteria which produce lipopolysaccharide (LPS) having the function of a toxin. In order to make a toxic effect the polymer must be separated from the cell outer membrane and presented to the immunocompetent ...
V. I. Tynyanova, E. P. Sokolova, V. P. Zyuzina, G. V. Demidova   +3 more
doaj   +1 more source

A genetic study of a Staphylococus aureus plasmid involving cure and transference

São Paulo Medical Journal
High frequency transfer and elimination of drug resistance may indicate an extrachromosomal inheritance of genetic determinants. This study shows the cure and transfer of a small plasmid and tetracycline resistance in Staphylococcus aureus 1030 (55)TetR ...
Ana Lúcia Costa Darini
doaj   +1 more source

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

eLife
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna   +6 more
doaj   +1 more source

Reciprocal extrachromosomal inheritance in barley: the transmission of an infective element through male and female gametes

Suomen Maataloustieteellisen Seuran Tiedote
My backcross pollinations of 53 spontaneum barleys recurrently with cv. ‘Adorra’ resulted in a maternally inherited, partial spike fertility case assigned “58”. Abnormal kernels, embryos and pollen, triploidy, miniature and streaked plants were among other symptoms. The 58-element greatly enhanced expression of the P-43 multi-ovary mutant in cv. ‘Paavo’
Hannu Ahokas
openalex   +4 more sources

Causes and consequences of bacterial local adaptation via MGEs in the plant microbiome

New Phytologist, EarlyView.
Summary Adaptations that enable plant‐associated bacteria to fill disparate niches comprise a critical component of microbial diversity. Genes that confer locally adaptive bacterial traits, ranging from heavy metal resistance to pathogen or symbiont infectivity, often reside within mobile genetic elements (MGEs) that can move between genomes.
Stephanie Porter, Dominique Holtappels, Angeliqua Montoya, Britt Koskella   +3 more
wiley   +1 more source

Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture

Reviews in Aquaculture, Volume 18, Issue 1, January 2026.
The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos, Francesc Padrós, Maria Constenla, Ana Jerončić, Dimitra Kogiannou, Sofia Consuegra, Mikolaj Adamek, Ivona Mladineo   +7 more
wiley   +1 more source

Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing

Cell Reports
Summary: The non-Mendelian inheritance of extrachromosomal DNA (ecDNA) exacerbates tumor genomic heterogeneity and evolution. Due to short-read sequencing’s reconstruction deficiencies, ecDNA abundance in clinical tumor tissues requires further ...
Ruoming Sun, Zongkai Li, Yi Liu, Yanbing Hou, Bowen Zhao, Chunpeng Chen, Jingwen Fang, Chuang Guo, Ying Zhou, Kun Qu, Shouzhen Li   +10 more
doaj   +1 more source

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions

MedComm, Volume 6, Issue 12, December 2025.
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun, Yunwei Sun, Ling Lan, Siyuan Luan, Jin Zhou, Jiehui Deng, Yong Yuan, Zhong Wu   +7 more
wiley   +1 more source

Plasmid Copy Number Variation Impacts Pathogenicity and Quantification of Curtobacterium flaccumfaciens pv. flaccumfaciens Infecting Mung Bean

Plant Pathology, Volume 74, Issue 9, Page 2670-2681, December 2025.
Dynamic plasmid copy numbers in the bacterial pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens influence disease expression in mung beans. ABSTRACT In bacteria, plasmids can confer the ability to cause disease. Although they can potentially vary in copy number, little has been reported on the dynamics of plasmids in plant‐pathogenic bacteria ...
Ahmed Saad, Niloofar Vaghefi, Barsha Poudel, Anthony J. Young, Lisa A. Kelly, Noel L. Knight   +5 more
wiley   +1 more source