Results 31 to 40 of about 2,768 (134)

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, Volume 19, Issue 11, Page 2999-3002, November 2025.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

CURRENT OPINION ON TAXONOMY, MORPHOLOGICAL, AND FUNCTIONAL PROPERTIES OF BIFIDOBACTERIA

Фундаментальная и клиническая медицина, 2018
Here we present current information on the taxonomy of bifidobacteria, which is based on their phenotypic, genetic and phylogenetic characteristics.
YULIYА V. Zakharova, LYUDMILA A. Levanova   +1 more
doaj  

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

Nature Communications
Borgs are huge extrachromosomal elements (ECE) of anaerobic methane-consuming “Candidatus Methanoperedens” archaea. Here, we used nanopore sequencing to validate published complete genomes curated from short reads and to reconstruct new genomes.
Marie C. Schoelmerich, Lynn Ly, Jacob West-Roberts, Ling-Dong Shi, Cong Shen, Nikhil S. Malvankar, Najwa Taib, Simonetta Gribaldo, Ben J. Woodcroft, Christopher W. Schadt, Basem Al-Shayeb, Xiaoguang Dai, Christopher Mozsary, Scott Hickey, Christine He, John Beaulaurier, Sissel Juul, Rohan Sachdeva, Jillian F. Banfield   +18 more
doaj   +1 more source

Review for "Can non‐Mendelian inheritance of extrachromosomal circular DNA‐mediated EPSPS gene amplification provide an opportunity to reverse resistance to glyphosate?"

, 2021
Todd A. Gaines
openalex   +2 more sources

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, Volume 24, Issue 8, August 2025.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

Therapies for Mitochondrial Disease: Past, Present, and Future

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Mitochondrial disease is a diverse group of clinically and genetically complex disorders caused by pathogenic variants in nuclear or mitochondrial DNA‐encoded genes that disrupt mitochondrial energy production or other important mitochondrial pathways. Mitochondrial disease can present with a wide spectrum of clinical features and can often be
Megan Ball, Nicole J. van Bergen, Alison G. Compton, David R. Thorburn, Shamima Rahman, John Christodoulou   +5 more
wiley   +1 more source

Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution [PDF]

Abstract Gene amplification in the form of extrachromosomal DNA (ecDNA) is a frequent driver in multiple cancer types. As ecDNA lack centromeres, their mitotic segregation does not follow traditional inheritance principles. However, the mechanisms that govern ecDNA fate following mitosis remain unclear. We found that ecDNA undergo numerical
Shir Marom, Inbar Lifshits Dayan, Venkata Narasimha Kadali, Mădălina Giurgiu-Kraljič, Gabriela Koifman, Karen Hakeny, Madhuri Chaurasia, Orléna Benamozig, Reinat Nevo, Ido Azuri, Julia Ryvkin, Ron Rotkopf, Gil Stelzer, Nino Oniashvili, Jacques Mardoukh, Sarah Pollock, Nika Iremadze, Zohar Shipony, Meital Kupervaser, Noa Wigoda, Dena Leshkowitz, Zvulun Elazar, Esther Berko, Anton G. Henssen, Ofer Shoshani   +24 more
openaire   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

DNA damage response pathway is a promising therapeutic target for extrachromosomal DNA‐positive tumours

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Congcong Tian, Haiyun Gan
wiley   +1 more source