Results 81 to 90 of about 1,654,064 (188)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

21 | Differential lung ventilation and extracorporeal CO₂ removal as rescue strategy in severe post-traumatic acute respiratory distress syndrome – a case report

Emergency Care Journal
Background. Major trauma is a recognized risk factor for Acute Respiratory Distress Syndrome (ARDS), resulting from direct lung injury (e.g. pulmonary contusions) or indirect mechanisms mediated by inflammation and endothelial dysfunction. Trauma-related
Emanuele Rollo, Monisa Xhihani, Leonardo Nanna, Francesco Grittani, Claudio Laterza, Manuela Fioriello, Claudio Zimatore, Antonio Sforza, Mary J. Mura Ondok, Vito Laguaragnella, Dafne Pisani, Mario Ribezzi, Antonio Civita, Luigi Pisani, Salvatore Grasso, Marco V. Ranieri   +15 more
doaj   +1 more source

Extracorporeal lung support for hypercapnic ventilatory failure

, 2018
Extracorporeal lung support can be achieved using extracorporeal membrane oxygenation (ECMO) and extracorporeal CO2 removal. The ECMO systems allow a total lung support, providing both blood oxygenation and CO2 removal.
Pisani, Lara, Nava, Stefano, Pacilli, Angela Maria Grazia, Polastri, Massimiliano   +3 more
core   +1 more source

A mathematical model of respiration under protective ventilation and extracorporeal CO2 removal therapy [PDF]

, 2017
The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency.
Dauby, Pierre, Habran, Simon, MORIMONT, Philippe, Desaive, Thomas, LAMBERMONT, Bernard   +4 more
core   +1 more source

Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO2 removal. A comparison with continuous positive pressure ventilation

, 1980
Six lambs were anesthetized and connected venovenous mode to a Membrane Lung for Extracorporeal CO2 removal. The animals underwent several hours periods of continuous positive pressure ventilation (CPPV), at 5 cmH2O positive end expiratory pressure (PEEP)
D. Cantaluppi, C. Bernasconi, G. Damia, A. Agostoni, A. Pelizzola, L. Tarenzi, L. Gattinoni, G. P. Rossi   +7 more
core   +1 more source

Extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

Trials, 2019
Background Chronic obstructive pulmonary disease (COPD) is a common cause of chronic respiratory failure and its course is punctuated by a series of acute exacerbations which commonly lead to hospital admission.
Nicholas A. Barrett, Eirini Kostakou, Nicholas Hart, Abdel Douiri, Luigi Camporota   +4 more
doaj   +1 more source

Update on the role of extracorporeal CO2 removal

, 2015
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015.
MORIMONT, Philippe, BATCHINSKY, Andriy, LAMBERMONT, Bernard   +2 more
openaire   +1 more source

Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial

Intensive Care Medicine Experimental
Background Lung- and diaphragm-protective (LDP) ventilation may prevent diaphragm atrophy and patient self-inflicted lung injury in acute respiratory failure, but feasibility is uncertain.
Damian Ratano, Binghao Zhang, Jose Dianti, Dimitrios Georgopoulos, Laurent J. Brochard, Timothy C. Y. Chan, Ewan C. Goligher   +6 more
doaj   +1 more source

Extracorporeal CO2 Removal (ECCO2R): Hope or Hype?

International Journal of Innovative Research in Medical Science
Recent technological advancements have simplified the design of extracorporeal membrane oxygenation devices, paving the way for specialized devices dedicated to the targeted removal of carbon dioxide (CO2) from the body. These CO2 removal devices feature a more streamlined configuration compared to traditional extracorporeal membrane oxygenation ...
Dr Mohammad Abbas, Dr Mohammad Fakruddin, Dr Shainaz Tabassum, Dr Farzana Begum   +3 more
openaire   +1 more source

Intraoperative extracorporeal carbon dioxide removal support for minimally invasive surgical treatment of vanishing lung syndrome

, 2020
Vanishing lung syndrome is a rare disease that could be treated successfully in selected cases with bullectomy. Protective ventilation is very important during surgery to achieve optimal post-operative results and to prevent complications.
Boschetto G., Schiavon M., Pangoni A., Rea F., Bellini A., Dell'Amore A., Serra E., Monaci N.   +7 more
core   +1 more source