Results 61 to 70 of about 1,654,064 (188)

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, Volume 38, Issue 55, 1 October 2026.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source

Extracorporeal Co2 removal in hypercapnic patients at risk of noninvasive ventilation failure. A matched cohort study with historical control

, 2015
Objectives: To assess efficacy and safety of noninvasive ventilation-plus-extracorporeal Co2 removal in comparison to noninvasive ventilation-only to prevent endotracheal intubation patients with acute hypercapnic respiratory failure at risk of failing ...
Urbino, Rosario, D'Amato, Raffaele, Sucre, Maria José, Evangelista, Andrea, Simonetti, Umberto, Dell'Amore, Andrea, MASCIA, LUCIANA, Antro, Camillo, PISANI, LARA, FILIPPINI, CLAUDIA, Persico, Pietro, Fanelli, Vito, Nava, Stefano, Ranieri, V. Marco, Terragni, Pierpaolo, Del Sorbo, Lorenzo, Fasano, Luca, Ranieri, Vito Marco   +17 more
core   +1 more source

Key Role of Respiratory Quotient to Reduce the Occurrence of Hypoxemia During Extracorporeal Gas Exchange: A Theoretical Analysis

, 2020
Objectives: Extracorporeal respiratory support, including low blood flow systems providing mainly extracorporeal CO2 removal, are increasingly applied in clinical practice.
Bottino, Nicola, Zanella, Alberto, Cipriani, Elisa, Nicola Bottino, Pesenti, Antonio, Giacomo Grasselli, Antonio Pesenti, Alberto Zanella, Eleonora Carlesso, Brusatori, Serena, Elisa Cipriani, Serena Brusatori, Thomas Langer, Langer, Thomas, Grasselli, Giacomo, Carlesso, Eleonora, Colombo, Sebastiano Maria, Sebastiano Maria Colombo   +17 more
core   +1 more source

Simultaneous 3‐D Adiabatic T1ρ, T2*, and Quantitative Susceptibility Mapping for Characterization of Myocardial Infarction in Ex Vivo Mouse

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
This study combines segmented T1ρ preparation into a 3‐D gradient‐echo sequence for simultaneous quantitative susceptibility, T2*, and T1ρ mapping of infarcted mouse hearts ex vivo. The method enabled assessment of T1ρ and T2* relaxation time maps and magnetic susceptibility, with ischemic regions clearly identified by all contrasts and consistent with
Iida Räty, Olli Nykänen, Sanna Kettunen, Svetlana Laidinen, Anna‐Kaisa Ruotsalainen, Mikko J. Nissi, Elias Ylä‐Herttuala   +6 more
wiley   +1 more source

Impact of membrane lung surface area and blood flow on extracorporeal CO2 removal during severe respiratory acidosis

Intensive Care Medicine Experimental, 2017
Background Veno-venous extracorporeal CO2 removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and the membrane surface areas range
Christian Karagiannidis, Stephan Strassmann, Daniel Brodie, Philine Ritter, Anders Larsson, Ralf Borchardt, Wolfram Windisch   +6 more
doaj   +1 more source

Atelectasis, Shunt, and Worsening Oxygenation Following Reduction of Respiratory Rate in Healthy Pigs Undergoing ECMO: An Experimental Lung Imaging Study

Frontiers in Physiology, 2021
Rationale: Reducing the respiratory rate during extracorporeal membrane oxygenation (ECMO) decreases the mechanical power, but it might induce alveolar de-recruitment. Dissecting de-recruitment due to lung edema vs.
Elena Spinelli, Giulia Colussi, Gaia Dal Santo, Eleonora Scotti, Ines Marongiu, Erica Garbelli, Alessandra Mazzucco, Daniele Dondossola, Daniele Dondossola, Raquel Maia, Raquel Maia, Michele Battistin, Osvaldo Biancolilli, Lorenzo Rosso, Lorenzo Rosso, Stefano Gatti, Tommaso Mauri, Tommaso Mauri   +17 more
doaj   +1 more source

Alkaline Liquid Ventilation of the Membrane Lung for Extracorporeal Carbon Dioxide Removal (ECCO₂R): In Vitro Study [PDF]

, 2021
Extracorporeal carbon dioxide removal (ECCO2R) is a promising strategy to manage acute respiratory failure. We hypothesized that ECCO2R could be enhanced by ventilating the membrane lung with a sodium hydroxide (NaOH) solution with high CO2 absorbing ...
Zanella, Alberto, Stefano Gatti, Pesenti, Antonio, Giacomo Grasselli, Todaro, Serena, Antonio Pesenti, Michele Battistin, Carlo Valsecchi, Gaetano Florio, Alberto Zanella, Eleonora Carlesso, Luigi Vivona, Thomas Langer, Serena Todaro, Florio, Gaetano, Langer, Thomas, Grasselli, Giacomo, Carlesso, Eleonora, Gatti, Stefano, Battistin, Michele, Colombo, Sebastiano Maria, Valsecchi, Carlo, Sebastiano Maria Colombo, Vivona, Luigi   +23 more
core   +1 more source

Physiological effects of adding ECCO2R to invasive mechanical ventilation for COPD exacerbations

Annals of Intensive Care, 2020
Background Extracorporeal CO2 removal (ECCO2R) could be a valuable additional modality for invasive mechanical ventilation (IMV) in COPD patients suffering from severe acute exacerbation (AE). We aimed to evaluate in such patients the effects of a low-to-
J.-L. Diehl, L. Piquilloud, D. Vimpere, N. Aissaoui, E. Guerot, J. L. Augy, M. Pierrot, D. Hourton, A. Arnoux, C. Richard, J. Mancebo, A. Mercat   +11 more
doaj   +1 more source

Reverse‐Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy

Small, Volume 22, Issue 55, 1 October 2026.
Bioinspired triglyceride‐ceramide lipid nanoparticles were reverse‐engineered from cytokine‐sequestering plant‐derived nanoparticles to capture pathological inflammatory mediators through protein corona formation. Dexamethasone‐loaded TCNPs combine extracellular cytokine sequestration with intracellular immunomodulation, reducing IL‐6, TNF‐α, and NF‐κΒ
Junsik J. Sung, Gargi Yogesh Digholkar, Ryan M. Pearson   +2 more
wiley   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, Volume 6, Issue 5, October 2026.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source