Results 51 to 60 of about 1,654,064 (188)

Respiratory Electrodialysis. A Novel, Highly Efficient Extracorporeal CO2 Removal Technique [PDF]

American Journal of Respiratory and Critical Care Medicine, 2015
Abstract Rationale We developed an innovative, minimally invasive, highly efficient extracorporeal CO2 removal (ECCO2R) technique called respiratory electrodialysis (R-ED). Objectives To evaluate the efficacy of R-ED ...
ZANELLA, ALBERTO, CASTAGNA, LUIGI, SALERNO, DOMENICO, SCARAVILLI, VITTORIO, El Sayed Deab, S, MAGNI, FEDERICO, GIANI, MARCO, Mazzola, S, Albertini, M, PATRONITI, NICOLO' ANTONINO, MANTEGAZZA, FRANCESCO, PESENTI, ANTONIO MARIA   +11 more
openaire   +2 more sources

Low flow extracorporeal CO2 removal in ARDS patients: a prospective short-term crossover pilot study

BMC Anesthesiology, 2017
Background Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis.
Harlinde Peperstraete, Sunny Eloot, Pieter Depuydt, Filip De Somer, Carl Roosens, Eric Hoste   +5 more
doaj   +1 more source

Experimental Extracorporeal Circulation System: A Pilot Study in Rats

Artificial Organs, EarlyView.
A miniature extracorporeal circulation (ECC) system was developed for reproducible rodent studies. This system incorporates an integrated heat exchanger and a silicone membrane oxygenator within a double‐lumen circuit, resulting in an ultralow priming volume of < 1.5 mL.
Akira T. Kawaguchi, Kaori Inukai, Mayuko Shibata, Gen T. Kawaguchi, Kazuaki Sato, Taiga Aburaya, Jacob Bergsland, Yoshiyuki Yamada   +7 more
wiley   +1 more source

Veno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model [PDF]

, 2015
peer reviewedBACKGROUND: Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung.
BLAFFART, Francine, B. LAMBERMONT, T. DESAIVE, J.‐O. DEFRAIGNE, HELLA, Dominique, J. GUIOT, MORIMONT, Philippe, TCHANA-SATO, Vincent, GUIOT, Julien, Defraigne, Jean-Olivier, D. HELLA, V. TCHANA‐SATO, JANSSEN, Nathalie, F. BLAFFART, A. CAGNINA, P. MORIMONT, Desaive, Thomas, CAGNINA, A, LAMBERMONT, Bernard, N. JANSSEN   +19 more
core   +1 more source

A Minimally Invasive and Highly Effective Extracorporeal CO2 Removal Device Combined With a Continuous Renal Replacement Therapy

, 2022
Objectives: Extracorporeal carbon dioxide removal is used to treat patients suffering from acute respiratory failure. However, the procedure is hampered by the high blood flow required to achieve a significant CO2 clearance.
Zanella, Alberto, Vittorio Scaravilli, Luca Di Girolamo, Pesenti, Antonio, Ilaria Protti, Federica Pirrone, Alberto Zanella, Michele Battistin, Biancolilli, Osvaldo, Eleonora Scotti, Stefano De Falco, Osvaldo Biancolilli, Pirrone, Federica, Mattia Busana, Busana, Mattia, Gatti, Stefano, Colombo, Sebastiano Maria, Battistin, Michele, Domenico Salerno, Salerno, Domenico, Daniele Dondossola, Stefano Gatti, Giacomo Grasselli, Antonio Pesenti, Protti, Ilaria, Gori, Francesca, Di Girolamo, Luca, Scaravilli, Vittorio, De Falco, Stefano, Andrea Carlin, Carlin, Andrea, Grasselli, Giacomo, Dondossola, Daniele, Scotti, Eleonora, Francesca Gori, Sebastiano Maria Colombo   +35 more
core   +1 more source

Progress Toward a Portable Artificial Lung: A Systematic Review

Artificial Organs, EarlyView.
Eight portable respiratory assist devices were identified. The CE‐marked MobyBox and the FDA‐approved Breethe OXY‐1 system are in clinical use. Each device is substantially minimized to allow ambulation, but further work is required to address challenges related to anticoagulant management and safe mobilization. Created in BioRender. Svendsen, A. (2026)
Maja Munk Svendsen, Clara Kjær Hendriksen, Lars Folkersen, Peter Juhl‐Olsen, Leila Louise Benhassen, Søren Nielsen Skov   +5 more
wiley   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease

Annals of Intensive Care, 2022
Background Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV).
Nicholas A. Barrett, Nicholas Hart, Kathleen J. R. Daly, Martina Marotti, Eirini Kostakou, Chris Carlin, Stephanie Lua, Suveer Singh, Andrew Bentley, Abdel Douiri, Luigi Camporota   +10 more
doaj   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Extracorporeal carbon dioxide removal for treatment of exacerbated chronic obstructive pulmonary disease (ORION): study protocol for a randomised controlled trial

Trials, 2021
Background Hypercapnic exacerbations are severe complications of chronic obstructive pulmonary disease (COPD), characterized by negative impact on prognosis, quality of life and healthcare costs.
Tommaso Tonetti, Lara Pisani, Irene Cavalli, Maria Laura Vega, Elisa Maietti, Claudia Filippini, Stefano Nava, V. Marco Ranieri   +7 more
doaj   +1 more source