Results 61 to 70 of about 2,047 (196)

Serum Nectin‐4 as a Potential Prognostic Biomarker for Extramammary Paget Disease

Experimental Dermatology, Volume 34, Issue 10, October 2025.
ABSTRACT Nectin cell adhesion molecule 4 (Nectin‐4) is overexpressed in the tissue of extramammary Paget disease (EMPD), and its potential role as a circulating biomarker remains poorly explored. We therefore investigated serum levels of Nectin‐4 in EMPD patients and healthy controls by ELISA assay and analysed its clinical relevance.
Hiromichi Morita, Takuya Miyagawa, Kenta Oka, Okuto Iwasawa, Hinako Saito, Toko Mori, Hisao Kawashima, Jun Omatsu, Daisuke Yamada, Shinichi Sato   +9 more
wiley   +1 more source

A case of extramammary inguinal Paget disease in a male patient: surgical treatment with an abdominal advancement cutaneous flap [PDF]

, 2017
Extramammary Paget disease (EMPD) is a rare neoplasm. The clinical case of a 55-year-old man with a two-year history of a pruritic, painless erythematous skin rash on the inguinal region and scrotum is described.
Brandi, Cesare, Cuomo, Roberto, D'Aniello, Carlo, Grimaldi, Luca, Milonia, Luca, Nisi, Giuseppe, Sisti, Andrea, Tassinari, Juri   +7 more
core   +1 more source

Comprehensive management of vulvovaginal cancers

CA: A Cancer Journal for Clinicians, Volume 75, Issue 5, Page 410-435, September/October 2025.
Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues, Maaike H. M. Oonk, Domenica Lorusso, Brian Slomovitz, Mario M. Leitão Jr, Glauco Baiocchi   +5 more
wiley   +1 more source

Cancer of the vulva: 2025 update

International Journal of Gynecology &Obstetrics, Volume 171, Issue S1, Page 36-47, September 2025.
Abstract Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. No specific screening exists and the most effective strategy to reduce the incidence of vulvar cancer is the opportune treatment of predisposing and preneoplastic lesions associated with its development.
Alexander B. Olawaiye, Mauricio A. Cuello, Sushil Beriwal, Linda J. Rogers   +3 more
wiley   +1 more source

The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients [PDF]

, 2017
BACKGROUND: The role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant NDc on the surgical approach to the nipple-areola complex, and (ii) to verify the ...
AC Wolff, AK Schecter, Anna Sapino, B Pritt, BW Kooistra, C Tomasovic-Loncaric, Carla Pecchioni, Caterina Marchiò, CR de Potter, Davide Balmativola, EF Brachtel, Elena Vissio, Francesca Montarolo, Francesca Muscarà, GA Lammie, H El-Daly, H Gulay, HP Leis Jr, I Castellano, Isabella Castellano, Ivana Sarotto, J Wang, Janina Kulka, Jasna Metovic, JE Rusby, JR Morales Piato, K Meissner, L Cataliotti, L Chen, L Weidong, Laura Annaratone, LD Louie, Luigia Macrì, M D'Alonzo, M Morrogh, M Niemeyera, MJ Carvalho, N Cabioglu, Nelson Rangel, Paola Cassoni, R Ponzone, RA Wolber, Riccardo Arisio, RJ Gray, RL Bauer, RM Simmons, RT Dolan, RY Chang, S Zervoudis, SY Wang, V Sacchini, William B. Coleman, WY Lee, Z Vlajcic   +53 more
core   +2 more sources

Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature [PDF]

, 2011
Extramammary Paget's disease (EMPD) is an uncommon intraepithelial neoplasm that most commonly arises on the vulva and perianal region. Very few cases of EMPD revealing a histological Bowenoid appearance have been reported.
Bark-Lynn Lew, Cannavò, Hawley, Matsumoto, Mazoujian, Mobini, Orlandi, Quinn, Rayne, Williamson, Woo-Young Sim, Yu-Jin Oh   +11 more
core   +2 more sources

Genital Psoriasis: Shining Light on This Hidden Disease

JEADV Clinical Practice, Volume 4, Issue 4, Page 719-731, September 2025.
Psoriasis occurring on skin of the genital and perigenital regions has specific diagnostic and treatment requirements due to the sensitivity and private nature of these areas. A multidisciplinary group of experts in the management of genital psoriasis, the Genital Psoriasis Wellness Consortium, convened to discuss the impact of genital psoriasis on ...
Jennifer Cather, Melodie Young, Muriel Boreham, Shehla Admani, Tina Bhutani, Erin Foster, Richard Fried, Melinda Gooderham, Jeannette Jakus, Sandra Johnson, Ryoichi Kamide, John Koo, Tiffany Mayo, Michael Payette, Caitriona Ryan, Lucinda Whitney, Krista Bohnert, Melissa Seal, Patrick Burnett, Diane Hanna   +19 more
wiley   +1 more source

Improving imiquimod use in cervical high‐grade squamous intraepithelial lesions: A qualitative study

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 9, Page 1712-1719, September 2025.
Adequate patient counselling on imiquimod treatment, including the possible application methods and potential side effects, along with optimal guidance during treatment, contributes to a better patient experience and reduces the likelihood of early discontinuation of treatment.
Caroline L. P. Muntinga, Helena C. J. Schellekens, Charlotte G. J. Penders, Hélène van Meir, Gatske M. Nieuwenhuyzen‐De Boer, Anna J. M. van de Sande, Heleen J. van Beekhuizen, Peggy J. de Vos Van Steenwijk, Ruud L. M. Bekkers, Edith M. G. van Esch   +9 more
wiley   +1 more source

Absence of microsatellite instability in extramammary Paget's disease

Skin Health and Disease, 2021
Background Deficiency of DNA mismatch repair (MMR) induces microsatellite instability (MSI). Pembrolizumab, an antibody targeting PD‐1 (an immune checkpoint inhibitor), is more effective against MMR‐deficient tumours than against MMR‐proficient tumours ...
K. Kashiwada‐Nakamura, T. M. Myangat, I. Kajihara, Y. Kusaba, K. Tanaka, R. Sakamoto, S. Maeda‐Otsuka, S. Yamada‐Kanazawa, S. Sawamura, H. Kanemaru, Y. Nishimura, N. Honda, K. Makino, A. Miyashita, J. Aoi, T. Igata, T. Makino, S. Masuguchi, S. Fukushima, H. Ihn   +19 more
doaj   +1 more source

Usefulness of sentinel lymph node biopsy for prognostic prediction inextramammary Paget’s disease [PDF]

, 2016
埼玉医科大学平成28年
緒方 大
core