Results 121 to 130 of about 26,166 (275)

Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model

Frontiers in Synaptic Neuroscience, 2019
N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival.
Rujun Kang, Liang Wang, Shaun S. Sanders, Kurt Zuo, Michael R. Hayden, Lynn A. Raymond   +5 more
doaj   +1 more source

C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors [PDF]

, 2000
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional regulation at central excitatory synapses.
Kennedy, Mary B., Köhr, Georg, Schenker, Leslie T., Schulz, Torsten W., Seeburg, Peter H., Steigerwald, Frank   +5 more
core   +1 more source

GAERS are resistant to migraine-provoking agents: The role of extrasynaptic GABAA receptors [PDF]

, 2023
Berkay Alpay, Barışcan Çimen, E Akaydin, Filiz Onat, Hayrünnisa Bolay, Yıldırım Sara   +5 more
openalex   +1 more source

Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner

Nature Communications, 2019
Hippocampal hyperactivity is correlated with psychosis in schizophrenia patients and likely attributable to deficits in GABAergic signaling. Here we attempt to reverse this deficit by overexpression of the α5-GABAA receptor within the ventral hippocampus
J. Donegan, Angela M Boley, J. Yamaguchi, G. Toney, D. Lodge   +4 more
semanticscholar   +1 more source

Adjunctive acetazolamide for drug‐resistant seizures in SLC6A1‐related neurodevelopmental disorder: An exploratory case series

Epilepsia Open, Volume 10, Issue 6, Page 2009-2017, December 2025.
Abstract Pathogenic variants in SLC6A1 cause a neurodevelopmental disorder characterized by developmental delay with behavioral disturbances, seizures, often pharmacoresistant, and a spectrum of movement disorders such as ataxia. A similar triad is observed in other monogenic conditions, such as SLC2A1, CHD2, and CACNA1A‐related disorders, where ...
Gia Melikishvili, Olivier Dulac, Otar Koniashvili, Giorgi Mamardashvili, Tamar Gachechiladze, Nazhi Tabatadze, Mariam Melikishvili, Rimma Gamirova, Tatyana Tomenko, Igor Bakhtin, Amber Freed, Elena Bossi, Bruria Ben‐Zeev, Gerhard Kluger, Antonio Falace, Antonella Riva, Kai Kaila, Pasquale Striano   +17 more
wiley   +1 more source

Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex

Frontiers in Neuroscience, 2018
Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability.
Saraí Trujeque-Ramos, Diego Castillo-Rolón, Elvira Galarraga, Dagoberto Tapia, Gabina Arenas-López, Stefan Mihailescu, Salvador Hernández-López   +6 more
doaj   +1 more source

DMV extrasynaptic NMDA receptors regulate caloric intake in rats

JCI Insight, 2021
Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA ...
Courtney Clyburn, R. Alberto Travagli, Amy C. Arnold, Kirsteen N. Browning   +3 more
doaj   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, Volume 11, Issue 4, Page 457-475, Winter 2025.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

Neurobiology of Disease, 2012
We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingtin ...
Austen J. Milnerwood, Alexandra M. Kaufman, Marja D. Sepers, Clare M. Gladding, Lily Zhang, Liang Wang, Jing Fan, Ainsley Coquinco, Joy Yi Qiao, Hwan Lee, Yu Tian Wang, Max Cynader, Lynn A. Raymond   +12 more
doaj   +1 more source

Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein [PDF]

, 2000
Background: Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-adhesion molecules and components of second messenger cascades into synapses, and are therefore potentially important for co-ordinating synaptic strength and structure.
Thomas, U., Ebitsch, S., Gorczyca, M., Koh, Y.H., Hough, C.D., Woods, D., Gundelfinger, E.D., Budnik, V.   +7 more
core   +1 more source