Results 51 to 60 of about 70,107 (293)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Axionic charged black branes with arbitrary scalar nonminimal coupling

European Physical Journal C: Particles and Fields, 2019
In this paper, we construct four-dimensional charged black branes of a nonminimally coupled and self-interacting scalar field. In addition to the scalar and Maxwell fields, the model involves two axionic fields homogeneously distributed along the two ...
Adolfo Cisterna, Luis Guajardo, Mokhtar Hassaine   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Probing 4-Dimensional Nonsupersymmetric Black Holes Carrying D0- and D6-brane charges [PDF]

, 1998
We discuss a 4-dimensional nonsupersymmetric black hole solution to low energy type IIA string theory which carries D0- and D6-brane charges. For equal charges this solution reduces to the one discussed recently by Sheinblatt.
Avinash Dhar, Bachas, Banks, Banks, Callan, Chodos, Das, de Wit, de Wit, Dhar, Dobiasch, Douglas, Dowker, Duff, Duff, Gautam Mandal, Gibbons, Gibbons, Gibbons, Horowitz, Hull, Kabat, Lifschytz, Lifschytz, Lifschytz, Maldacena, Maldacena, Maldacena, Pollard, Sen, Strominger   +30 more
core   +2 more sources

D = 5 rotating black holes in Einstein-Gauss-Bonnet gravity: mass and angular momentum in extremality

Journal of High Energy Physics, 2021
We consider perturbative solutions in Einstein gravity with higher-derivative extensions and address some subtle issues of taking extremal limit. As a concrete new result, we construct the perturbative rotating black hole in five dimensions with equal ...
Liang Ma, Yue-Zhou Li, H. Lü
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Boundedness of the extremal solutions in dimension 4 [PDF]

, 2012
In this paper we establish the boundedness of the extremal solution u^* in dimension N=4 of the semilinear elliptic equation $-\Delta u=\lambda f(u)$, in a general smooth bounded domain Omega of R^N, with Dirichlet data $u|_{\partial \Omega}=0$, where f ...
Villegas, Salvador
core  

Extremal rotating black holes in Einstein-Maxwell-Chern-Simons theory: radially excited solutions and non-uniqueness

, 2015
We study 5-dimensional black holes in Einstein-Maxwell-Chern-Simons theory with free Chern-Simons coupling parameter. We consider an event horizon with spherical topology, and both angular momenta of equal magnitude.
Blazquez-Salcedo, Jose Luis
core   +1 more source

Logarithmic corrections for near-extremal Kerr-Newman Black holes

Journal of High Energy Physics
In this paper, we computed the logarithmic corrections of entropy for the near-extremal Kerr-Newman black holes in N $$ \mathcal{N} $$ = 2 supergravity theory applying the Euclidean path integral approach in near-horizon geometry.
Ashes Modak, Aditya Singh, Binata Panda
doaj   +1 more source

Non-perturbative decay of non-Abelian hair

Journal of High Energy Physics, 2017
We construct a solution of Heterotic supergravity which interpolates between two different AdS3 × S3 × T4 geometries corresponding to the near-horizon limits of two 5-dimensional black holes, only one of which has non-Abelian hair.
Pablo A. Cano, Tomás Ortín
doaj   +1 more source