Results 61 to 70 of about 2,223 (301)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A neighboring extremal solution for optimal switched impulsive control problems with large perturbations [PDF]
, 2012 This paper presents an approach to compute the neighboring extremal solution for an optimal switched impulsive control problem with a pre-specified sequence of modes and a large perturbation in the initial state.
Loxton, Ryan +3 more
core
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Regularity of the Extremal Solution in a MEMS Model with Advection [PDF]
Methods and Applications of Analysis, 2008 8 pages. Updated versions --if any-- of this author's papers can be downloaded at http://www.birs.ca/~nassif/
Cowan, Craig, Ghoussoub, Nassif
openaire +3 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Particle acceleration near a rotating charged black hole in 4D Einstein-Gauss-Bonnet gravity
Nuclear Physics BWe investigate the horizon structure and ergosphere in a charged rotating black hole within 4D Einstein-Gauss-Bonnet gravity, which introduces additional parameters (Q) because of the charge and Gauss-Bonnet parameter (β), besides the mass (M) and ...
Abdurakhmon Nosirov +4 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Perturbing singular solutions of the Gelfand problem
, 2008 he equation $-\Delta u = \lambda e^u$ posed in the unit ball $B \subseteq \R^N$, with homogeneous Dirichlet condition $u|_{\partial B} = 0$, has the singular solution $U=\log\frac1{|x|^2}$ when $\lambda = 2(N-2)$.
Dupaigne, Louis, Davila, Juan
core +2 more sources