Results 71 to 80 of about 3,418,189 (307)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Existence and comparison results for quasilinear evolution hemivariational inequalities
Electronic Journal of Differential Equations, 2004 We generalize the sub-supersolution method known for weak solutions of single and multivalued nonlinear parabolic problems to quasilinear evolution hemivariational inequalities.
Siegfried Carl +2 more
doaj
Particle acceleration near a rotating charged black hole in 4D Einstein-Gauss-Bonnet gravity
Nuclear Physics BWe investigate the horizon structure and ergosphere in a charged rotating black hole within 4D Einstein-Gauss-Bonnet gravity, which introduces additional parameters (Q) because of the charge and Gauss-Bonnet parameter (β), besides the mass (M) and ...
Abdurakhmon Nosirov +4 more
doaj +1 more source
Extremal solutions for measure differential inclusions via Stieltjes derivatives
Advances in Difference Equations, 2019 Stieltjes derivatives represent a new unification of discrete and continuous calculus consisting in a differentiation process with respect to a given non-decreasing function g.
Giselle A. Monteiro, Bianca Satco
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Rare Events, Temporal Dependence and the Extremal Index [PDF]
AMS classifications: 60G70; 62G32;block maximum;exceedance;extremal index;failure set;mixing condition;M4 process;rare event;stationary ...
Segers, J.J.J.
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Extremal solution to generalized differential equations under integral boundary condition
, 2021 In this article, by utilizing the monotone iterative strategy coupled with the strategy of upper and lower solutions, we get the existence of extremal iteration solution to generalized differential equations under boundary conditions of type Riemann ...
Vivas Cortez, Miguel José
core +2 more sources
Regularity of stable solutions to semilinear elliptic equations on Riemannian models
Advances in Nonlinear Analysis, 2015 We consider the reaction-diffusion problem -Δgu = f(u) in ℬR with zero Dirichlet boundary condition, posed in a geodesic ball ℬR with radius R of a Riemannian model (M,g).
Castorina Daniele, Sanchón Manel
doaj +1 more source