Results 61 to 70 of about 69,875 (273)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Quasilinearization method for an impulsive integro-differential system with delay
Mathematical Biosciences and Engineering, 2022 In this paper, we obtain solution sequences converging uniformly and quadratically to extremal solutions of an impulsive integro-differential system with delay. The main tools are the method of quasilinearization and the monotone iterative.
Bing Hu +3 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Einstein-Maxwell-scalar black holes: classes of solutions, dyons and extremality
Journal of High Energy Physics, 2019 Spherical black hole (BH) solutions in Einstein-Maxwell-scalar (EMS) models wherein the scalar field is non-minimally coupled to the Maxwell invariant by some coupling function are discussed. We suggest a classification for these models into two classes,
D. Astefanesei +3 more
doaj +1 more source
4D and 2D Evaporating Dilatonic Black Holes
, 1993 The picture of S-wave scatering from a 4D extremal dilatonic black hole is examined. Classically, a small matter shock wave will form a non-extremal black hole. In the "throat region" the r-t geometry is exactly that of a collapsing 2D black hole. The 4D
Peleg, Yoav
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Extremal solutions of quasilinear parabolic subdifferential inclusions
Differential and Integral Equations, 2003 The authors consider the following initial boundary value problem for the quasilinear parabolic inclusion: \[ \frac{\partial u}{\partial t}+Au+\beta(\cdot,u)\ni Fu+h \quad {\text{in}} \;Q, \qquad u(x,0)=0\;{\text{in}}\;\Omega \quad{\text{and}}\;u=0\;{\text{on}}\;\Gamma, \] where \(\Omega\subseteq\mathbb{R}^N\) is a bounded domain with Lipschitz ...
Carl, Siegfried, Motreanu, Dumitru
openaire +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source