Results 81 to 90 of about 57,690 (307)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Logarithmic corrections for near-extremal black holes

Journal of High Energy Physics
We present the computation of logarithmic corrections to near-extremal black hole entropy from one-loop Euclidean gravity path integral around the near-horizon geometry. We extract these corrections employing a suitably modified heat kernel method, where
Nabamita Banerjee, Muktajyoti Saha, Suthanth Srinivasan   +2 more
doaj   +1 more source

Electro-magnetic energy extraction from rotating black holes in AdS

Journal of High Energy Physics, 2020
Force-Free Electrodynamics for black holes in Anti de Sitter is considered. We present new, energy extracting solutions of Force-Free Electrodynamics in Anti de Sitter-Near Horizon Extremal Kerr and Super-Entropic Near Horizon Extremal Kerr geometries ...
Nele Callebaut, Maria J. Rodriguez, Herman Verlinde   +2 more
doaj   +1 more source

Large Charge Four-Dimensional Non-Extremal N=2 Black Holes with R^2-Terms [PDF]

, 2009
We consider N=2 supergravity in four dimensions with small R^2 curvature corrections. We construct large charge non-extremal black hole solutions in all space, with either a supersymmetric or a non-supersymmetric extremal limit, and analyze their ...
Arkani-Hamed N, Bak D Kim S Rey S J, Cardoso G L, Cardoso G L, Eyal Gruss, Gruss E, Gruss E, Hubeny V, Jacobson T Kang G Myers R C, Kats Y, Sahoo B, Sen A, Tripathy P K   +12 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Instabilities of microstate geometries with antibranes

, 2015
One can obtain very large classes of horizonless microstate geometries corresponding to near-extremal black holes by placing probe supertubes whose action has metastable minima inside certain supersymmetric bubbling solutions.
Bena, Iosif, Pasini, Giulio
core   +1 more source

From p-branes to Cosmology [PDF]

, 1996
We study the relationship between static p-brane solitons and cosmological solutions of string theory or M-theory. We discuss two different ways in which extremal p-branes can be generalised to non-extremal ones, and show how wide classes of recently ...
Brandenberger R., C. N. POPE, Copeland E. J., H. LÜ, Hull C. M., Kaloper N., Larsen F., Lü H., S. MUKHERJI   +8 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Entropy function for rotating extremal black holes in very special geometry [PDF]

, 2007
We use the relation between extremal black hole solutions in five- and in four-dimensional N=2 supergravity theories with cubic prepotentials to define the entropy function for extremal black holes with one angular momentum in five dimensions.
A. Dabholkar, A. Sen, B. Sahoo, B. Sahoo, B.E.W. Nilsson, D. Astefanesei, D. Astefanesei, D. Gaiotto, D. Gaiotto, G.L. Cardoso, G.L. Cardoso, G.W. Gibbons, Gabriel L Cardoso, J.F. Morales, Jan Perz, Johannes M Oberreuter, M. Günaydin, N. Itzhaki   +17 more
core   +2 more sources