Results 61 to 70 of about 7,673,385 (305)

Relevance of Lipid-Based Products in the Management of Dry Eye Disease

Journal of Ocular Pharmacology and Therapeutics, 2017
Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to facilitate the optimal transmission of light.
J. Garrigue, M. Amrane, Marie-Odile Faure, J. Holopainen, L. Tong   +4 more
semanticscholar   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Chronic environmental temperature affects protein expression in the eye of adult zebrafish (Danio rerio)

Scientific Reports
Vision in vertebrates is mediated by the eye, a complex organ with developmental and functional similarities to the central nervous system. Eye proteomics has emerged as a powerful tool for investigating ocular function and disease mechanisms, including ...
Elisa Maffioli, Simona Nonnis, Francesca Grassi Scalvini, Joshua Grana, Armando Negri, Flavia Frabetti, Gabriella Tedeschi, Mattia Toni   +7 more
doaj   +1 more source

Drosophila photoreceptors and signaling mechanisms

Frontiers in Cellular Neuroscience, 2009
Fly eyes have been a useful biological system in which fundamental principles of sensory signaling have been elucidated. The physiological optics of the fly compound eye, which was discovered in the Musca, Calliphora and Drosophila flies, has been widely
Ben Katz, Baruch Minke
doaj   +1 more source

Neurofilament light chain in the vitreous humor of the eye

Alzheimer’s Research & Therapy, 2020
Background Neurofilament light chain (NfL) is a promising biomarker of neurodegeneration in the cerebrospinal fluid and blood. This study investigated the presence of NfL in the vitreous humor and its associations with amyloid beta, tau, inflammatory ...
Manju L. Subramanian, Viha Vig, Jaeyoon Chung, Marissa G. Fiorello, Weiming Xia, Henrik Zetterberg, Kaj Blennow, Madeleine Zetterberg, Farah Shareef, Nicole H. Siegel, Steven Ness, Gyungah R. Jun, Thor D. Stein   +12 more
doaj   +1 more source

A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. [PDF]

PLoS ONE, 2017
Ubiquitination is a crucial post-translational modification that can target proteins for degradation. The E3 ubiquitin ligases are responsible for recognizing substrate proteins for ubiquitination, hence providing specificity to the process of protein ...
Kwami F Ketosugbo, Henry L Bushnell, Ruth I Johnson   +2 more
doaj   +1 more source

Candidate Molecular Compounds as Potential Indicators for Meibomian Gland Dysfunction

Frontiers in Medicine, 2022
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease throughout the world. Studies have shown that several molecules in meibum, including but not limited to interleukins, amino acids, cadherins, eicosanoids, carbohydrates, and ...
Kofi Asiedu
doaj   +1 more source

Proteomic analysis of human lacrimal and tear fluid in dry eye disease

Scientific Reports, 2017
To understand the pathophysiology of dry eye disease (DED), it is necessary to characterize proteins in the ocular surface fluids, including tear fluid (TF) and lacrimal fluid (LF).
J. Jung, Yong Woo Ji, H. Hwang, J. Oh, Hyun Chang Kim, H. Lee, K. Kim   +6 more
semanticscholar   +1 more source

The Eyes Absent Proteins in Developmental and Pathological Angiogenesis [PDF]

The American Journal of Pathology, 2016
Management of neoangiogenesis remains a high-value therapeutic goal. A recently uncovered association between the DNA damage repair pathway and pathological angiogenesis could open previously unexplored possibilities for intervention. An attractive and novel target is the Eyes absent (EYA) tyrosine phosphatase, which plays a critical role in the repair
Yuhua, Wang, Emmanuel, Tadjuidje, Ram Naresh, Pandey, James A, Stefater, Lois E H, Smith, Richard A, Lang, Rashmi S, Hegde   +6 more
openaire   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source