Results 71 to 80 of about 7,673,385 (305)

Refractive index gradient in the lens: reflections on form and function and on the lens paradox

Frontiers in Ophthalmology
IntroductionThe eye lens is a sophisticated optical element that provides the eye with both refractive power and transparency as well as the ability to change focus.
Barbara K. Pierscionek
doaj   +1 more source

Planar polarity in primate cone photoreceptors: a potential role in Stiles Crawford effect phototropism

Communications Biology, 2022
Verschueren et al. expand our understanding of the Stiles-Crawford effect in mammals by using super-high resolution expansion microscopy of the adult macaque eye.
Anna Verschueren, Leyna Boucherit, Ulisse Ferrari, Stéphane Fouquet, Céline Nouvel-Jaillard, Michel Paques, Serge Picaud, José-Alain Sahel   +7 more
doaj   +1 more source

A new eye on NLR proteins: focused on clarity or diffused by complexity?

Current Opinion in Immunology, 2012
The nucleotide-binding domain leucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology.
Vera Bonardi, K. Cherkis, Marc T. Nishimura, J. Dangl   +3 more
semanticscholar   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Notes on electropherograms of eye-lens, muscle proteins and zymograms of muscle esterases of fish collected during the first Brazilian expedition to the Antarctica

Brazilian Journal of Oceanography, 1985
A preliminary study was carried out on electropherograms of eye-lens, muscle proteins and zymograms of muscle esterases of ten Notothenia larseni, six Notothenia nudifrons and one lanternfish, Electrona antarctica.
Van Ngan Phan, Hana Suzuki, Vicente Gomes, Maria José de Arruda Campos Rocha Passos   +3 more
doaj   +1 more source

Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress

Antioxidants, 2020
Background: Hyperglycemia-induced oxidative stress plays a key role in diabetic complications, including diabetic retinopathy. The main goal of this study was to assess whether the topical administration (eye drops) of glucagon-like peptide-1 (GLP-1) has
Hugo Ramos, Patricia Bogdanov, Joel Sampedro, Jordi Huerta, Rafael Simó, Cristina Hernández   +5 more
doaj   +1 more source

VEGF mRNA and protein concentrations in the developing human eye [PDF]

Pediatric Research, 2015
Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurity. However, the ontogeny of VEGF expression in the human fetal retina is not well known.
Irene T. Ma, Suzanne McConaghy, Kopperuncholan Namachivayam, Brian A. Halloran, Ashish R. Kurundkar, Krishnan MohanKumar, Akhil Maheshwari, Robin K. Ohls   +7 more
openaire   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.

PLoS ONE, 2012
Dry eye syndrome (DES) is a complex, multifactorial, immune-associated disorder of the tear and ocular surface. DES with a high prevalence world over needs identification of potential biomarkers so as to understand not only the disease mechanism but also
Saijyothi Venkata Aluru, Shweta Agarwal, Bhaskar Srinivasan, Geetha Krishnan Iyer, Sivakumar M Rajappa, Utpal Tatu, Prema Padmanabhan, Nirmala Subramanian, Angayarkanni Narayanasamy   +8 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source