Results 81 to 90 of about 7,673,385 (305)

The quantification of zebrafish ocular-associated proteins provides hints for sex-biased visual impairments and perception

Heliyon
Biochemical differences between sexes can also be seen in non-sexual organs and may affect organ functions and susceptibility to diseases. It has been shown that there are sex-biased visual perceptions and impairments.
Hamid Niksirat, Valentina Siino, Christoph Steinbach, Fredrik Levander   +3 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Electrophoretic study on intraspecific variations and interspecific relationships of marine catfishes (Siluriformes, Ariidae) of Cananéia (São Paulo, Brazil): 1. General proteins of eye-lens and skeletic muscle

Brazilian Journal of Oceanography, 1990
Cellulose acetate electrophoresis of eye-lens proteins and Polyacrylamide flat gel electrophoresis of skeletic muscle proteins of six species of marine catfishes were carried out. Genetic polymorphism only occured at one locus of the electropherograms of
Hana Suzuki, Van Ngan Phan
doaj   +1 more source

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients

Scientific Reports, 2016
Despite the high global prevalence of dry eye syndrome (DES), the fundamental processes underlying this pathology remain largely unexplored. Therefore, this study endeavoured to investigate in-depth the tear proteome of DES patients employing the mass ...
Natarajan Perumal, S. Funke, N. Pfeiffer, F. Grus   +3 more
semanticscholar   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Retinol-binding protein is synthesized in the mammalian eye

Biochemical and Biophysical Research Communications, 1988
As the chromophoric component of the visual pigment, retinol plays an essential role in vision. In the plasma, retinol is transported by retinol-binding protein (RBP) in complex with transthyretin (TTR, prealbumin). In previous work we demonstrated intraocular synthesis of TTR.
R L, Martone, E A, Schon, D S, Goodman, D R, Soprano, J, Herbert   +4 more
openaire   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Calcium channel-dependent molecular maturation of photoreceptor synapses. [PDF]

PLoS ONE, 2013
Several studies have shown the importance of calcium channels in the development and/or maturation of synapses. The Ca(V)1.4(α(1F)) knockout mouse is a unique model to study the role of calcium channels in photoreceptor synapse formation.
Nawal Zabouri, Silke Haverkamp
doaj   +1 more source

Mechanism and evidence of nonsense suppression therapy for genetic eye disorders

Experimental Eye Research, 2017
Between 5 and 70% of genetic disease is caused by in‐frame nonsense mutations, which introduce a premature termination codon (PTC) within the disease‐causing gene. Consequently, during translation, non‐functional or gain‐of‐function truncated proteins of
R. Richardson, M. Smart, D. Tracey-White, A. Webster, M. Moosajee   +4 more
semanticscholar   +1 more source