Results 101 to 110 of about 27,341 (230)

STUDYING MOLECULAR MODELLING OF THE CHOLESTEROL ABSORPTION INHIBITOR EZETIMIBE AND EVALUATION OF ITS ANTIBACTERIAL ACTIVITY [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
As is known, ezetimibe is the only drug classified as a cholesterol absorption inhibitor, working by preventing the cholesterol transporter protein Niemann-Pick C1-Like 1 (NPC1L1) from functioning.
Manila Mohammed, Saleh Trefi, Mustapha Chehna, Yaser Bitar, Ali Ibrahim   +4 more
doaj   +1 more source

Combination of bempedoic acid, ezetimibe, and atorvastatin in patients with hypercholesterolemia: A randomized clinical trial.

Atherosclerosis, 2020
BACKGROUND AND AIMS Many patients with hypercholesterolemia fail to achieve sufficient low-density lipoprotein cholesterol (LDL-C) lowering despite use of guideline-recommended lipid-lowering therapies.
J. Rubino, D. Macdougall, L. Sterling, J. Hanselman, S. Nicholls   +4 more
semanticscholar   +1 more source

Simultaneous Analysis of Antihyperlipidemic Drug Combinations by Green High‐Performance Liquid Chromatography Using Design of Experiments

SEPARATION SCIENCE PLUS, Volume 9, Issue 7, July 2026.
ABSTRACT Cardiovascular diseases are the leading cause of worldwide mortality, often supported by intricate dyslipidemic patterns of high levels of low‐density lipoprotein cholesterol and triacylglycerol. HMG‐CoA reductase inhibitors (statins) and ezetimibe can be used synergistically to treat these pathologies, as they target distinct metabolic ...
Venkatesh Bukkapatnam, Raja Sundararajan
wiley   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Pharmacokinetic non-interaction analysis in a fixed-dose formulation in combination of atorvastatin and ezetimibe

Frontiers in Pharmacology, 2014
Recent clinical research has shown that atorvastatin in combination with cholesterol absorption inhibitor ezetimibe significantly reduces LDL-C level in patients with hypercholesterolemia, showing a superior lipid-lowering efficacy compared to statin ...
Omar ePatiño-Rodríguez, Irma eTorres-Roque, Maricela eMartínez-Delgado, Abraham eEscobedo-Moratilla, José ePérez-Urizar   +4 more
doaj   +1 more source

Non-statin lipid-lowering therapy over time in very-high-risk patients: effectiveness of fixed-dose statin/ezetimibe compared to separate pill combination on LDL-C

Clinical Research in Cardiology, 2020
Many patients at very-high atherosclerotic cardiovascular disease risk do not reach guideline-recommended targets for LDL-C. There is a lack of data on real-world use of non-statin lipid-lowering therapies (LLT) and little is known on the effectiveness ...
J. Katzmann, F. Sorio-Vilela, E. Dornstauder, Uwe Fraas, T. Smieszek, S. Zappacosta, U. Laufs   +6 more
semanticscholar   +1 more source

Disease‐Associated Remodeling of m6A RNA Methylation in Human Interstitial Cells From Fibro‐Calcific Aortic Valves

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Direct RNA sequencing of primary human valvular interstitial cells (VICs) from non‐calcified control and fibro‐calcific aortic stenosis (AS) valves reveals disease‐associated remodeling of m6A RNA methylation. AS‐derived VICs show an overall increase in detected m6A sites, together with transcript‐specific hyper‐ and hypo‐methylation patterns ...
Vincenza Valerio, Omar Molla, Ilaria Massaiu, Gloria Garoffolo, Veronika A. Myasoedova, Mattia Chiesa, Paolo Poggio   +6 more
wiley   +1 more source

Effect of ezetimibe on blood lipids.

, 2015
Semi-fasted blood lipid levels of obese hyperlipidemic hamsters treated for 14 days with vehicle (PO, QD) or Ezetimibe (10.0 mg/kg, PO, QD).
Louise S. Dalbøge (420563), Gitte Hansen (521571), Katrine Fabricius (782439), Niels Vrang (420564), Henrik B. Hansen (782440), Jacob Jelsing (420565), Philip J. Pedersen (782438)   +6 more
core   +1 more source

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

Science Advances, 2020
Details of intestinal sterol absorption and inhibition by cholesterol-lowering drug are uncovered in new protein structures. The intestinal absorption of cholesterol is mediated by a multipass membrane protein, Niemann-Pick C1-Like 1 (NPC1L1), the ...
Ching-Shin Huang, Xinchao Yu, P. Fordstrom, Kaylee Choi, B. C. Chung, S. Roh, W. Chiu, Mingyue Zhou, Xiaoshan Min, Zhulun Wang   +9 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source