Results 131 to 140 of about 27,341 (230)
Food Science &Nutrition, Volume 14, Issue 6, June 2026.A bacteria‐enzyme synergistic fermentation process using Lactobacillus rhamnosus was developed to produce fermented Ganoderma lucidum broth (FBG), which significantly enriched ganoderic acid F compared to water extraction. In FFA‐induced HepG2 cells, FBG alleviated NAFLD‐related damage by reducing lipid deposition, ROS, MDA, TC, TG, and LDL‐C, while ...
Manhui Sun +6 more
wiley +1 more source
Ezetimibe: New perspectives in lipid lowering treatment
, 2007 Therapeutic goals for lipid lowering treatment in the prevention of ischemic heart disease are often not reached in clinical practice. Even the highest doses of statins do not guarantee good control of hypercholesterolemia in all patients. Therefore, new
Jankowski, Piotr; 1st Clinic of Cardiology University Hospital, Cracow, Poland +2 more
core
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi +4 more
wiley +1 more source
Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis
ChemistryOpen, Volume 15, Issue 6, June 2026.This review highlights synthetic advances (2013–2025) in intramolecular C─N bond formation for constructing the pharmaceutically relevant pyrrolidine core. The review is organized into five methodological clusters: 1) intramolecular alkene/alkyne amination; 2) tandem annulations, which involve C─N bond formation as the key step; 3) nucleophilic ...
Rasma Kroņkalne, Māris Turks
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Tolvaptan is widely used as an adjunct oral diuretic to loop and thiazide diuretics for the management of fluid overload in patients with congestive heart failure. Recently, tolvaptan sodium phosphate (TSP), a water‐soluble prodrug of tolvaptan, was developed for intravenous administration and has demonstrated efficacy and safety in clinical ...
Takaya Uno +10 more
wiley +1 more source
The effect of ezetimibe on NAFLD
, 2015 NAFLD has become the most common liver disorder in countries, where obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome are common. The strong association between these conditions and the risk of cardiovascular disease make treatment ...
AVERNA, Maurizio
core +1 more source
Clinical Transplantation, Volume 40, Issue 6, June 2026.ABSTRACT Introduction Current guidelines recommend evaluation for coronary artery disease prior to lung transplantation. Coronary artery calcium scores obtained using non‐gated, non‐contrast computed tomography scans may help predict major adverse cardiovascular events following transplant.
Daniel N. Cook +6 more
wiley +1 more source
Hepatology Research, Volume 56, Issue 6, Page 887-902, June 2026.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, with an increasing number of patients progressing to cirrhosis and hepatocellular carcinoma (HCC). Early identification of individuals at high risk for advanced fibrosis is essential for preventing liver‐related ...
Norio Akuta +44 more
wiley +1 more source
Design and Characterization of Nanocrystal Formulations Containing Ezetimibe
, 2011 Ezetimibe is a lipid-lowering compound that selectively inhibits the absorption of cholesterol and related phytosterols from the intestine As ezetimibe is almost Insoluble in water, its bioavailability is too low to be detected Thus, the objective of ...
Oner, Levent +2 more
core +1 more source
Journal of Evaluation in Clinical Practice, Volume 32, Issue 4, June 2026.ABSTRACT Introduction Cardiovascular and cerebrovascular diseases are projected to expand in the coming decades as the main cause of death. This study outlines the escalating burden of cardiovascular diseases in low‐ and middle‐income countries (LMICs), particularly in Latin America (LA), which is expected to surpass that of other high‐population ...
Renato de Carvalho Barros +22 more
wiley +1 more source