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2011
Ezetimibe is a drug substance which can be used for lowering low-density lipoprotein cholesterol. Its crystal form and polymorphism have been determined using X-ray diffraction and thermal methods. Quantitative and qualitative analysis of Ezetimibe as well as study of its impurities and degradations were summarized in this chapter.
Maria L A D, Lestari +2 more
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Ezetimibe is a drug substance which can be used for lowering low-density lipoprotein cholesterol. Its crystal form and polymorphism have been determined using X-ray diffraction and thermal methods. Quantitative and qualitative analysis of Ezetimibe as well as study of its impurities and degradations were summarized in this chapter.
Maria L A D, Lestari +2 more
openaire +3 more sources
Expert Opinion on Drug Safety, 2009
Treatments with ezetimibe/simvastatin (combined or alone) have been indicated as very promising approaches to strongly reduce cholesterol levels in hyperlipidemic patients.We will discuss the efficacy and safety of ezetimibe/simvastatin and their potential to reduce atheroprogression.
MONTECUCCO, FABRIZIO +2 more
openaire +4 more sources
Treatments with ezetimibe/simvastatin (combined or alone) have been indicated as very promising approaches to strongly reduce cholesterol levels in hyperlipidemic patients.We will discuss the efficacy and safety of ezetimibe/simvastatin and their potential to reduce atheroprogression.
MONTECUCCO, FABRIZIO +2 more
openaire +4 more sources
Journal of Pharmaceutical and Biomedical Analysis, 2015
The aminolysis of ezetimibe (1) and the structurally similar (3R*,4S*)-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-methylazetidin-2-one (4a) giving the corresponding β-aminoamides 2a-d and 5a-c was studied spectrophotometrically under pseudo-first order conditions in aqueous butylamine, 3-methoxypropylamine, 2-methoxyethylamine and 2-hydroxyethylamine ...
Jana, Baťová +2 more
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The aminolysis of ezetimibe (1) and the structurally similar (3R*,4S*)-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-methylazetidin-2-one (4a) giving the corresponding β-aminoamides 2a-d and 5a-c was studied spectrophotometrically under pseudo-first order conditions in aqueous butylamine, 3-methoxypropylamine, 2-methoxyethylamine and 2-hydroxyethylamine ...
Jana, Baťová +2 more
openaire +2 more sources
The American Journal of Cardiology, 2009
The results of the SANDS substudy 2 require careful interpretation. It was a secondary, nonrandomized, observational study of highly selected subjects who required more lipid lowering than what a statin could provide to achieve the LDL cholesterol goal, and the baseline characteristics were different between the subgroups.
Hiroshi, Ashikaga +2 more
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The results of the SANDS substudy 2 require careful interpretation. It was a secondary, nonrandomized, observational study of highly selected subjects who required more lipid lowering than what a statin could provide to achieve the LDL cholesterol goal, and the baseline characteristics were different between the subgroups.
Hiroshi, Ashikaga +2 more
openaire +2 more sources
Expert Opinion on Investigational Drugs, 2002
Ezetimibe is a cholesterol absorption inhibitor that significantly lowers low- density lipoprotein cholesterol (LDL-C), and favourably affects triglyceride and high-density lipoprotein cholesterol blood levels in monotherapy and in combination with statins.
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Ezetimibe is a cholesterol absorption inhibitor that significantly lowers low- density lipoprotein cholesterol (LDL-C), and favourably affects triglyceride and high-density lipoprotein cholesterol blood levels in monotherapy and in combination with statins.
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Drug and Therapeutics Bulletin, 2009
▼Ezetimibe (Ezetrol – MSD-Schering Plough) is a lipid-lowering drug that reduces plasma concentrations of low-density lipoprotein (LDL) cholesterol and total cholesterol when used alone or in combination with a statin.1 In 2004, we could find no evidence on the effects of ezetimibe on cardiovascular morbidity and mortality and ...
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▼Ezetimibe (Ezetrol – MSD-Schering Plough) is a lipid-lowering drug that reduces plasma concentrations of low-density lipoprotein (LDL) cholesterol and total cholesterol when used alone or in combination with a statin.1 In 2004, we could find no evidence on the effects of ezetimibe on cardiovascular morbidity and mortality and ...
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DMW - Deutsche Medizinische Wochenschrift, 2004
H, Meyer Zu Schwabedissen, H K, Kroemer
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H, Meyer Zu Schwabedissen, H K, Kroemer
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