Results 71 to 80 of about 13,129,737 (272)
Self-assembly of CIP4 drives actin-mediated asymmetric pit-closing in clathrin-mediated endocytosis
Nature Communications, 2023 Clathrin-mediated endocytosis is pivotal to signal transduction pathways between the extracellular environment and the intracellular space. Evidence from live-cell imaging and super-resolution microscopy of mammalian cells suggests an asymmetric ...
Yiming Yu, Shige H. Yoshimura
doaj +1 more source
Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles [PDF]
Journal of Cell Science, 2008 PCH family proteins are fundamentally important proteins, linking membrane curvature events with cytoskeletal reorganisation. One group, the MEGAPs (also called srGAPs and WRPs) contain RhoGAP domains in addition to the F-BAR domain. We disrupted MEGAP1 and MEGAP2 in Dictyostelium both singly and in combination. We found a strong cytoskeletal phenotype
Robert J W, Heath, Robert H, Insall
openaire +2 more sources
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Nature Communications, 2016 Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens ...
Yvonne L. Dorland +13 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Membrane tubules induced by F-BAR domain lattice.
, 2013 (A) Membrane tubule formed by edge-to-edge fusion. As explained in the text, the end result of simulation TUBULATION, shown in Figure 6b, had its free edges forcibly fused, the resulting membrane tubule being presented here. The membrane tubule is shown
Hang Yu (278278) +1 more
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Structure and Analysis of FCHo2 F-BAR Domain: A Dimerizing and Membrane Recruitment Module that Effects Membrane Curvature [PDF]
Structure, 2007 A spectrum of membrane curvatures exists within cells, and proteins have evolved different modules to detect, create, and maintain these curvatures. Here we present the crystal structure of one such module found within human FCHo2. This F-BAR (extended FCH) module consists of two F-BAR domains, forming an intrinsically curved all-helical antiparallel ...
Henne, William Mike +9 more
openaire +2 more sources
A numerical model of the hydrodynamics of the thermal bar [PDF]
, 1995 The thermal bar phenomenon is modelled numerically by the natural convection of a fluid contained in a two-dimensional triangular domain. The non-rotating case considered here is appropriate to laboratory models of the thermal bar.
Farrow, D.E.
core