Results 81 to 90 of about 13,129,737 (272)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Toxoplasma membrane inositol phospholipid binding protein TgREMIND is essential for secretory organelle function and host infection

Cell Reports
Summary: Apicomplexan parasites possess specialized secretory organelles called rhoptries, micronemes, and dense granules that play a vital role in host infection.
Rodrigue Houngue, Lamba Omar Sangaré, Tchilabalo Dilezitoko Alayi, Aissatou Dieng, Tristan Bitard-Feildel, Claire Boulogne, Christian Slomianny, Cynthia Menonve Atindehou, Lucie Ayi Fanou, Yetrib Hathout, Isabelle Callebaut, Stanislas Tomavo   +11 more
doaj   +1 more source

F-BAR domain protein Rga7 collaborates with Cdc15 and Imp2 to ensure proper cytokinesis in fission yeast [PDF]

Journal of Cell Science, 2014
F-BAR domain proteins act as linkers between the cell cortex and cytoskeleton and are involved in membrane binding and bending. Rga7 is one of the seven F-BAR proteins present in fission yeast. In addition to the F-BAR domain at the N-terminal region, Rga7 possesses a Rho-GAP domain at its C-terminus.
Martín-García, Rebeca, Coll, Pedro M., Pérez González, Pilar   +2 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. [PDF]

PLoS ONE, 2010
Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42.
Wenyu Bu, Kim Buay Lim, Yuan Hong Yu, Ai Mei Chou, Thankiah Sudhaharan, Sohail Ahmed   +5 more
doaj   +1 more source

Direct interaction of actin filaments with F-BAR protein pacsin2

, 2014
Two mechanisms have emerged as major regulators of membrane shape: BAR domain-containing proteins, which induce invaginations and protrusions, and nuclear promoting factors, which cause generation of branched actin filaments that exert mechanical forces ...
Lehto, Veli Pekka, A. Orlova, Ismo Virtanen, I. Virtanen, Edward H Egelman, Juan Zou, Nikki, Marko, J. Rappsilber, U. Salzer, Oliviero Carugo, Ulrich Salzer, Steiner, Julia, J. Zou, J. Kostan, Hodnik, Vesna, J. Steiner, Djinović Carugo, Kristina, Y. Senju, P. Lappalainen, K. Djinovic Carugo, G. Anderluh, Yosuke Senju, J. Merilainen, Salzer, Ulrich, CARUGO, OLIVIERO ITALO, Lappalainen, Pekka, Schreiner, Claudia, V. Hodnik, Julia Steiner, Juri Rappsilber, V. P. Lehto, Julius Kostan, I. Toro, Rappsilber, Juri, Albina Orlova, Claudia Schreiner, Egelman, Edward H, Jari Meriläinen, Vesna Hodnik, Gregor Anderluh, Kostan, Julius, Veli‐Pekka Lehto, Meriläinen, Jari, Orlova, Albina, M. Nikki, Senju, Yosuke, Imre Törö, Kristina Djinović‐Carugo, Törö, Imre, Zou, Juan, Anderluh, Gregor, Marko Nikki, E. H. Egelman, C. Schreiner, Pekka Lappalainen, Virtanen, Ismo   +55 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Physicochemical Analysis from Real-Time Imaging of Liposome Tubulation Reveals the Characteristics of Individual F‑BAR Domain Proteins

, 2015
The Fer-CIP4 homology-BAR (F-BAR) domain, which was identified as a biological membrane-deforming module, has been reported to transform lipid bilayer membranes into tubules.
Shunsuke Yamada (1291752), Kingo Takiguchi (1280223), Kei Fujiwara (104718), Masatoshi Ichikawa (441720), Yohko Tanaka-Takiguchi (1280217), Akihisa Yamamoto (1291749), Toshiki Itoh (819017), Miho Yanagisawa (1274292), Kazuya Tsujita (1291746)   +8 more
core   +1 more source

Testing for seasonal unit roots in heterogeneous panels [PDF]

, 2004
This paper uses the approach of Im, Pesaran and Shin (2003) to propose seasonal unit root tests for dynamic heterogeneous panels based on the means of the individuals HEGY test statistics.
Giulietti, Monica, Smith, Jeremy, Otero, Jesus, Otero Cardona, Jesús Gilberto, Smith J., Giulietti M.   +5 more
core   +1 more source