Results 101 to 110 of about 13,129,737 (272)

Membrane curvature induced by lattices of F-BAR domains.

, 2013
(A) Dependence of membrane curvature on F-BAR domain density. Shown is curvature generated by lattices with F-BAR dimer densities of 5, 8, 10, 13 and 15 dimers per . A density of 10 dimers per generates the highest curvature, with radius of curvature . (
Hang Yu (278278), Klaus Schulten (102849)   +1 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Membrane tubulation by lattices of F-BAR domains.

, 2013
(A) Initial conformation of lattices of F-BAR domains on the membrane in a SBCG representation. A patch of membrane, 17 nm in width, is covered with 4 rows of F-BAR domains, each row containing 17 F-BAR domains.
Hang Yu (278278), Klaus Schulten (102849)   +1 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Molekulare Basis der SH3 Domänen Regulation der F-BAR vermittelten Membrandeformation

, 2011
Eukaryotic cells are characterized by a diverse array of membraneous structures including vesicles, tubules, and pleiomorphic vacuoles that enable cellular processes such as organelle biogenesis, cell division, cell migration, secretion, and endocytosis.
Rao, Yijian
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

eLife, 2014
The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active ...
Gunther Hollopeter, Jeffrey J Lange, Ying Zhang, Thien N Vu, Mingyu Gu, Michael Ailion, Eric J Lambie, Brian D Slaughter, Jay R Unruh, Laurence Florens, Erik M Jorgensen   +10 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis

Cell Reports, 2017
Clathrin/adaptor protein-1-coated carriers connect the secretory and the endocytic pathways. Carrier biogenesis relies on distinct protein networks changing membrane shape at the trans-Golgi network, each regulating coat assembly, F-actin-based ...
Mihaela Anitei, Christoph Stange, Cornelia Czupalla, Christian Niehage, Kai Schuhmann, Pia Sala, Aleksander Czogalla, Theresia Pursche, Ünal Coskun, Andrej Shevchenko, Bernard Hoflack   +10 more
doaj   +1 more source

Mechanisms of membrane organization and remodeling by septins and F-BAR domain

, 2023
Membranes are crucial to the cell’s life in all eukaryotic organisms. The organization of the plasma membrane is dynamic and can be modified during specific cellular functions such as cell division and endocytosis. Septins and F-BAR domain proteins are two groups of proteins with cellular functions that are linked to their ability to interact with the ...
openaire   +1 more source