The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase [PDF]
Nature Communications, 2023 The mitochondrial ATP synthase produces the bulk of cellular ATP. Here, the authors report a function of the mitochondrial Hsp70 in the formation of the catalytical head and in its assembly with the peripheral stalk to form the mature ATP synthase.
Jiyao Song +7 more
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A Bacterial Virulence Protein Promotes Pathogenicity by Inhibiting the Bacterium’s Own F1Fo ATP Synthase [PDF]
Cell, 2013 Several intracellular pathogens, including Salmonella enterica and Mycobacterium tuberculosis, require the virulence protein MgtC to survive within macrophages and to cause a lethal infection in mice. We now report that, unlike secreted virulence factors that target the host vacuolar ATPase to withstand phagosomal acidity, the MgtC protein acts on ...
Eun-Jin Lee +2 more
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Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging [PDF]
Microbial Cell, 2018 In aerobic organisms, mitochondrial F1Fo-ATP-synthase is the major site of ATP production. Beside this fundamental role, the protein complex is involved in shaping and maintenance of cristae.
Nadia G Rampello +3 more
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A mitochondrial megachannel resides in monomeric F1FO ATP synthase [PDF]
Nature Communications, 2019 The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels ...
Nelli Mnatsakanyan +6 more
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Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination. [PDF]
Sci Rep, 2020 AbstractDendritic spine injury underlies synaptic failure in many neurological disorders. Mounting evidence suggests a mitochondrial pathway of local nonapoptotic caspase signaling in mediating spine pruning. However, it remains unclear whether this caspase signaling plays a key role in spine loss when severe mitochondrial functional defects are ...
Chen H, Tian J, Guo L, Du H.
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The new role of F1Fo ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection. [PDF]
Exp Neurol, 2020 The mitochondrial F1Fo ATP synthase is one of the most abundant proteins of the mitochondrial inner membrane, which catalyzes the final step of oxidative phosphorylation to synthesize ATP from ADP and Pi. ATP synthase uses the electrochemical gradient of protons (ΔμH+) across the mitochondrial inner membrane to synthesize ATP.
Mnatsakanyan N, Jonas EA.
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The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans [PDF]
Nature Communications, 2021 F1Fo-ATP synthase is a key enzyme for energy production in fungi. Here, the authors show that the δ subunit of the enzyme is required for Candida albicans lethal infection and represents a potential therapeutic target.
Shuixiu Li +9 more
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Cristae architecture is determined by an interplay of the MICOS complex and the F1FO ATP synthase via Mic27 and Mic10 [PDF]
Microbial Cell, 2017 The inner boundary and the cristae membrane are connected by pore-like structures termed crista junctions (CJs). The MICOS complex is required for CJ formation and enriched at CJs. Here, we address the roles of the MICOS subunits Mic27 and Mic10.
Katharina Eydt +4 more
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Author Correction: Mitochondrial F1FO ATP synthase determines the local proton motive force at cristae rims [PDF]
EMBO ReportsBettina Rieger +4 more
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Obstruction of transmembrane helical movements in subunit a blocks proton pumping by F1Fo ATP synthase. [PDF]
J Biol Chem, 2013 Subunit a plays a key role in promoting H(+) transport-coupled rotary motion of the subunit c ring in F1Fo ATP synthase. H(+) binding and release occur at Asp-61 in the middle of the second transmembrane helix (TMH) of Fo subunit c. H(+) are thought to reach cAsp61 via aqueous half-channels formed by TMHs 2-5 of subunit a.
Moore KJ, Fillingame RH.
europepmc +6 more sources