Frontiers in Microbiology, 2018 Previous work has explored link between mitochondrial biology and fungal pathogenicity in F1Fo-ATP synthase in Candida albicans. In this work we have detailed the more specific roles of the F1Fo-ATP synthase β subunit, a key protein subunit of F1Fo-ATP ...
Shui-Xiu Li +15 more
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An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. [PDF]
Commun Biol, 2022 Hards K +21 more
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MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function. [PDF]
Protein SciAbstract Mitochondrial cristae architecture is central for optimal oxidative phosphorylation and a healthy mitochondrial physiology. The intricate architecture of the inner mitochondrial membrane relies on protein complexes that compartmentalize the membrane by imposing membrane curvature, forming membrane contact sites or membrane subdomains ...
Horten P, Song K, Pfanner N, Rampelt H.
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The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation [PDF]
Microbial Cell, 2017 Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase ...
Heike Rampelt, Martin van der Laan
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The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal. [PDF]
Front Oncol, 2014 The mitochondrial permeability transition pore (MPTP) is a non-specific pore in the inner mitochondrial membrane (IMM) whose opening is triggered by high matrix [Ca2+] to which it is sensitized by [Pi] and oxidative stress. MPTP opening plays a critical role in necrotic cell death such as in cardiac ischemia/reperfusion (I/R) injury and the action of ...
Halestrap AP.
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Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules. [PDF]
J Mol Evol, 2017 Niu Y +5 more
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Distinct structural features of Pseudomonas aeruginosa ATP synthase revealed by cryo-electron microscopy [PDF]
Nature CommunicationsF1Fo ATP synthase is the ubiquitous enzyme that synthesizes cellular ATP by coupling proton-motive force with rotational catalysis. Structural differences between prokaryotic and eukaryotic ATP synthases offer potential targets for antimicrobial ...
Meghna Sobti +8 more
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Natural products and other inhibitors of F1FO ATP synthase. [PDF]
Eur J Med Chem, 2020 F1FO ATP synthase is responsible for the production of >95% of all ATP synthesis within the cell. Dysregulation of its expression, activity or localization is linked to various human diseases including cancer, diabetes, and Alzheimer's and Parkinson's disease.
Patel BA, D'Amico TL, Blagg BSJ.
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Atypical Subunit Composition of the Chlorophycean Mitochondrial F1FO-ATP Synthase and Role of Asa7 Protein in Stability and Oligomycin Resistance of the Enzyme [PDF]
Molecular Biology and Evolution, 2010 Pierre Cardol +2 more
exaly +2 more sources
Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes. [PDF]
PLoS PathogensThe kinetoplast incorporates the large mitochondrial genome present in the eponymous Kinetoplastida. Trypanosoma brucei is an African trypanosome that can lose kinetoplast DNA (kDNA), however, when the nuclear-encoded gamma subunit of the mitochondrial ...
Melanie Ridgway +6 more
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