Results 31 to 40 of about 2,095 (173)

Fluid shear stress enhances proliferation of breast cancer cells via downregulation of the c-subunit of the F₁F_O ATP synthase. [PDF]

Biochem Biophys Res Commun, 2022
Park HA, Brown SR, Jansen J, Dunn T, Scott M, Mnatsakanyan N, Jonas EA, Kim Y.   +7 more
europepmc   +3 more sources

Mitochondrial permeability transition pore desensitization by a novel dispiranic derivative prevents cardiac reperfusion injury [PDF]

Redox Biology
Mitochondrial permeability transition pore (PTP) opening is a major determinant of cardiac ischemia/reperfusion (I/R) injury, contributing to cardiomyocyte death and impaired cardiac function following revascularization.
Giampaolo Morciano, Gaia Pedriali, Giulia Turrin, Cristina Algieri, Esther Densu Agyapong, Debora La Mantia, Chiara Bernardini, Giorgia Canini, Anna Fantinati, Elena Nicoletta Colarusso, Fabio Mollica, Daniela Ramaccini, Alessandra Pagliarani, Carlotta Giorgi, Elena Tremoli, Alessandro Arcovito, Salvatore Nesci, Claudio Trapella, Paolo Pinton   +18 more
doaj   +2 more sources

Mitochondrial F₁ F_O ATP synthase determines the local proton motive force at cristae rims. [PDF]

EMBO Rep, 2021
Rieger B, Arroum T, Arroum T, Borowski MT, Villalta J, Busch KB.   +5 more
europepmc   +3 more sources

Rethinking Mitchell's Chemiosmotic Theory: Potassium Dominates Over Proton Flux to Drive Mitochondrial F1Fo-ATP Synthase [PDF]

Function, 2022
Edoardo Bertero, Christoph Maack
doaj   +2 more sources

Mitochondrial cristae remodeling: Mechanisms, functions, and pathology [PDF]

Cell Insight
Mitochondrial cristae are the principal sites of oxidative phosphorylation and are central to mitochondria-dependent energy metabolism. Rather than static folds, cristae are dynamic bioenergetic compartments that remodel in response to physiological and ...
Jianglong Yu, Yuanchun Luo, Jiacheng Lin, Zhuofan Li, Zheng Fang, He He, Chaojun Yan, Zhiyin Song   +7 more
doaj   +2 more sources

The GPCR NMUR-1 mediates neural regulation of energy homeostasis in response to pathogen infection [PDF]

Infection and Immunity
A key challenge in immunology is understanding how the innate immune system achieves specificity against diverse pathogens. Our previous work in Caenorhabditis elegans identified NMUR-1, a neuronal G protein-coupled receptor homologous to mammalian ...
Phillip Wibisono, Yiyong Liu, Kenneth P. Roberts, Dodge Baluya, Jingru Sun   +4 more
doaj   +2 more sources

ATP Synthase K+- and H+-Fluxes Drive ATP Synthesis and Enable Mitochondrial K+-“Uniporter” Function: I. Characterization of Ion Fluxes

Function, 2022
ATP synthase (F1Fo) synthesizes daily our body's weight in ATP, whose production-rate can be transiently increased several-fold to meet changes in energy utilization.
Magdalena Juhaszova, Evgeny Kobrinsky, Dmitry B Zorov, H Bradley Nuss, Yael Yaniv, Kenneth W Fishbein, Rafael de Cabo, Lluis Montoliu, Sandra B Gabelli, Miguel A Aon, Sonia Cortassa, Steven J Sollott   +11 more
doaj   +1 more source

BNIP3 regulates cardiac energy metabolism by interaction with F1FO ATP-synthase [PDF]

European Heart Journal, 2022
Abstract Background The oxidative phosphorylation (OXPHOS) that takes place in the mitochondria produces chemical energy in form of ATP, the main energy source of the heart. Proper mitochondrial function determines the contractility of the heart.
Anna-Lena Beerlage, Stephan Settelmeier, Hannah Doepper, Jacqueline Heinen‐Weiler, Valentina Giorgio, T Rassaf, Ulrike B. Hendgen‐Cotta   +6 more
openalex   +2 more sources

Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth. [PDF]

PLoS ONE, 2015
We examined the thymoquinone induced inhibition of purified F1 or membrane bound F1FO E. coli ATP synthase. Both purified F1 and membrane bound F1FO were completely inhibited by thymoquinone with no residual ATPase activity. The process of inhibition was
Zulfiqar Ahmad, Thomas F Laughlin, Ismail O Kady   +2 more
doaj   +1 more source

Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex.

PLoS Pathogens, 2021
The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important pathogens of humans causing diseases such as toxoplasmosis and malaria, depend on ...
Andrew E Maclean, Hannah R Bridges, Mariana F Silva, Shujing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner   +6 more
doaj   +1 more source