Results 51 to 60 of about 2,095 (173)
Novel Drugs Targeting the c-Ring of the F1FO-ATP Synthase.
Mini reviews in medicinal chemistry, 2016 Increasing evidence highlights the role of the ATP synthase/hydrolase, also known as F1FO-complex, as key molecular and enzymatic switch between cell life and death, thus increasing the enzyme attractiveness as drug target in pharmacology. Being inhibition of ATP production usually linked to antiproliferative properties, drugs targeting the enzyme ...
PAGLIARANI, ALESSANDRA +2 more
openaire +3 more sources
Unusual features of the c-ring of F1FO ATP synthases [PDF]
Scientific Reports, 2019 AbstractMembrane integral ATP synthases produce adenosine triphosphate, the universal “energy currency” of most organisms. However, important details of proton driven energy conversion are still unknown. We present the first high-resolution structure (2.3 Å) of the in meso crystallized c-ring of 14 subunits from spinach chloroplasts.
A. V. Vlasov +15 more
openaire +6 more sources
Oxidative stress battles neuronal Bcl-xL in a fight to the death
Neural Regeneration Research, 2021 Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial membrane. Bcl-xL supports growth, development, and maturation of neurons, and it also prevents neuronal death during neurotoxic stimulation.
Han-A Park +2 more
doaj +1 more source
Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C‐ring conformation [PDF]
The EMBO Reports, 2017 The impact of the mitochondrial permeability transition (MPT) on cellular physiology is well characterized. In contrast, the composition and mode of action of the permeability transition pore complex (PTPC), the supramolecular entity that initiates MPT, remain to be elucidated.
Massimo Bonora +13 more
openalex +5 more sources
Rate Acceleration of ATP Hydrolysis by F1Fo-ATP Synthase [PDF]
Journal of Experimental Biology, 2000 ABSTRACT The rate acceleration of ATP hydrolysis by F1Fo-ATP synthase is of the order of 1011-fold. We present a cyclic enzyme mechanism for the reaction, relate it to known F1 X-ray structure and speculate on the linkage between enzyme reaction intermediates and subunit rotation.
A E, Senior, S, Nadanaciva, J, Weber
openaire +2 more sources
Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.
PLoS Pathogens, 2018 The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between hosts as well as survival ...
Caroline E Dewar +6 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Introduction: The ζ subunit is a potent inhibitor of the F1FO-ATPase of Paracoccus denitrificans (PdF1FO-ATPase) and related α-proteobacteria different from the other two canonical inhibitors of bacterial (ε) and mitochondrial (IF1) F1FO-ATPases.
Francisco Mendoza-Hoffmann +15 more
doaj +1 more source
Cell Reports, 2018 The biological roles of the three natural F1FO-ATPase inhibitors, ε, ζ, and IF1, on cell physiology remain controversial. The ζ subunit is a useful model for deletion studies since it mimics mitochondrial IF1, but in the F1FO-ATPase of Paracoccus ...
Francisco Mendoza-Hoffmann +8 more
doaj +1 more source
Redox Biology, 2021 Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences ROS levels is unclear.
Rubén Quintana-Cabrera +5 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana +2 more
wiley +1 more source