Results 71 to 80 of about 2,095 (173)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Insights into the regulatory function of the ɛ subunit from bacterial F-type ATP synthases: a comparison of structural, biochemical and biophysical data [PDF]

Open Biology, 2018
ATP synthases catalyse the formation of ATP, the most common chemical energy storage unit found in living cells. These enzymes are driven by an electrochemical ion gradient, which allows the catalytic evolution of ATP by a binding change mechanism.
Alexander Krah, Mariel Zarco-Zavala, Duncan G. G. McMillan   +2 more
doaj   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

Rotation of the c‐Ring Promotes the Curvature Sorting of Monomeric ATP Synthases

Advanced Science, 2023
ATP synthases are proteins that catalyse the formation of ATP through the rotatory movement of their membrane‐spanning subunit. In mitochondria, ATP synthases are found to arrange as dimers at the high‐curved edges of cristae.
David Valdivieso González, Marcin Makowski, M. Pilar Lillo, Francisco J. Cao‐García, Manuel N. Melo, Víctor G. Almendro‐Vedia, Iván López‐Montero   +6 more
doaj   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao   +10 more
wiley   +1 more source

A functionally inactive, cold-stabilized form of the Escherichia coli F1Fo ATP synthase

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006
An unusual effect of temperature on the ATPase activity of E. coli F1Fo ATP synthase has been investigated. The rate of ATP hydrolysis by the isolated enzyme, previously kept on ice, showed a lag phase when measured at 15 degrees C, but not at 37 degrees C. A pre-incubation of the enzyme at room temperature for 5 min completely eliminated the lag phase,
Galkin, M, Ishmukhametov, R, Vik, S
openaire   +3 more sources

Dextromethorphan Is a Novel Pharmacological Inhibitor of F1FO‐ATPase That Targets the Membrane‐Embedded Domain Impairing ATP Synthesis and Hydrolysis

BioFactors, Volume 52, Issue 1, January/February 2026.
Dextromethorphan selectively inhibits mitochondrial F1FO‐ATPase by targeting its membrane‐embedded domain, impairing ATP synthesis and hydrolysis without affecting electron transport, revealing a novel off‐target mechanism with implications for bioenergetic regulation.
Cristina Algieri, Antonia Cugliari, Silvia Granata, Patrycja Anna Glogowski, Fabiana Trombetti, Micaela Fabbri, Lucia Scainelli, Salvatore Nesci   +7 more
wiley   +1 more source

INA complex liaises the F1Fo-ATP synthase membrane motor modules

Nature Communications, 2017
The inner membrane assembly complex (INAC) interacts with components of the F1F0-ATP synthase but its function remains unclear. Here the authors show that INAC associates with two distinct complexes during F1F0-ATP synthase formation, which points ...
Nataliia Naumenko, Marcel Morgenstern, Robert Rucktäschel, Bettina Warscheid, Peter Rehling   +4 more
doaj   +1 more source

Mitochondrial flashes regulate ATP homeostasis in the heart

eLife, 2017
The maintenance of a constant ATP level (‘set-point’) is a vital homeostatic function shared by eukaryotic cells. In particular, mammalian myocardium exquisitely safeguards its ATP set-point despite 10-fold fluctuations in cardiac workload.
Xianhua Wang, Xing Zhang, Di Wu, Zhanglong Huang, Tingting Hou, Chongshu Jian, Peng Yu, Fujian Lu, Rufeng Zhang, Tao Sun, Jinghang Li, Wenfeng Qi, Yanru Wang, Feng Gao, Heping Cheng   +14 more
doaj   +1 more source

Bioenergetic profiles and respiratory control in mitochondrial physiology: Precision analysis of oxidative phosphorylation

Experimental Physiology, Volume 111, Issue 1, Page 179-211, 1 January 2026.
Abstract Oxidative phosphorylation (OXPHOS) is fundamental to mitochondrial function. Respirometry with living cells provides limited information compared to precision OXPHOS analysis with mitochondrial preparations, including isolated mitochondria, tissue homogenates, permeabilized tissues, and permeabilized cells.
Alba Timón‐Gómez, Carolina Doerrier, Zuzana Sumbalová, Luiz F. Garcia‐Souza, Eleonora Baglivo, Luiza H. D. Cardoso, Erich Gnaiger   +6 more
wiley   +1 more source