Results 81 to 90 of about 2,095 (173)
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early‐stage muscle dysfunction remain unclear.
Xiaolin Li +19 more
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Understanding structure, function, and mutations in the mitochondrial ATP synthase
Microbial Cell, 2015 The mitochondrial ATP synthase is a multimeric enzyme complex with an overall molecular weight of about 600,000 Da. The ATP synthase is a molecular motor composed of two separable parts: F1 and Fo. The F1 portion contains the catalytic sites for ATP
Ting Xu +2 more
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Scientific Reports, 2022 Mitochondrial dysfunction is a key element in the progression of Parkinson’s disease (PD). The inefficient operation of the electron transport chain (ETC) impairs energy production and enhances the generation of oxidative stress contributing to the loss ...
InHyeok Chung +9 more
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The Journal of Physiology, Volume 603, Issue 18, Page 4921-4949, September 15, 2025.Abstract figure legend An integrated model of human ventricular myocyte with excitation‐contraction‐energetics coupling was created to systematically analyse the contribution of Ca2+ regulation of mitochondrial enzymes to cardiomyocyte functions during workload transition; i.e. exercise.
Ayako Takeuchi, Satoshi Matsuoka
wiley +1 more source
Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.ABSTRACT In the alloplasmic lines of eggplant containing the cytoplasm of relative wild species, two types of cytoplasmic male sterility (CMS) are known: the pollen non‐formation (PN) type and the anther indehiscent (AI) type. The gene responsible for PN‐type CMS is presumed to be orf218, located in the mitochondrial genome.
Mai Tsujimura +8 more
wiley +1 more source
ChemMedChem, Volume 20, Issue 10, May 19, 2025.Targeting ATP synthase in Gram‐negative pathogens. Presented is the first disclosure of quinoline‐derived antibiotics inhibiting multidrug resistant Acinetobacter baumannii ATP synthase and expansion of the structure activity relationship profile of Pseudomonas aeruginosa ATP synthase inhibitors.
Katie T. Ward +9 more
wiley +1 more source
Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent
Advanced Science, Volume 12, Issue 20, May 29, 2025.This paper summarizes the latest applications and potential mechanisms of the rare earth element gadolinium in biomedical fields, in addition to its traditional application as an MRI contrast agent, including osteogenesis, antimicrobial, antitumor, bioimaging, bioprobes, and so on.
Xingtong Pan +9 more
wiley +1 more source
Engineered Living Energy Materials
Interdisciplinary Materials, Volume 4, Issue 3, Page 412-455, May 2025.Engineered living energy materials (ELEMs) are nascent research frontier for enabling sustainable energy conversion and storage. These materials exhibit unique characteristics such as self‐regeneration, biodegradability, environmental response, and evolutionary adaptability. This paper overviews different energy conversion bio‐modules, summarizes their
Xinyi Yuan +14 more
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The Spatio-Temporal Organization of Mitochondrial F1FO-ATP Synthase Is Determined by its Activity and Controlled by IF1 [PDF]
, 2021 Karin B. Busch +11 more
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Advanced Science, Volume 12, Issue 13, April 3, 2025.POU3F3 is significantly upregulated in non‐small cell lung cancer (NSCLC). Activated ERK1 directly interacts with and phosphorylates POU3F3, facilitating its nuclear translocation in NSCLC cells. Within the nucleus, POU3F3 functions as a transcription factor to enhance ATP5PF expression, thereby increasing the activity of mitochondrial complex V and ...
Qi‐Gang Zeng +14 more
wiley +1 more source