Results 61 to 70 of about 3,414,366 (288)

Survival Probabilities for Correlated Drifted Brownian Motions via Exit from Simplicial Cones

AppliedMath
This paper investigates the finite-horizon survival probability for a system of correlated arithmetic Brownian motions with heterogeneous drifts and volatilities, focusing on the event in which one component remains strictly below all others.
Tristan Guillaume
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Extensive vegetation management and semi-natural habitats increase plant alpha and gamma diversity in European vineyards

Basic and Applied Ecology
Permanent crops like vineyards have the potential to contribute to halting the biodiversity loss due to their spatiotemporal stability and lower disturbance frequency in vineyard inter-rows.
Silvia Winter, Ricarda Weitzl, Stefan Möth, Božana Petrović, Violette Aurelle, Pauline Tolle, Thomas Costes, Sylvie Richart-Cervera, Adrien Rusch   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The first monumental cemeteries of western Europe : the „Passy type“ necropolis in the Paris basin around 4500 BC

Journal of Neolithic Archaeology, 2010
In the Seine-Yonne basin at around 4500 B.C. numerous cemeteries appeared, including giant “enclosures” which as a funerary manifestation would have no later equivalent in Europe. These constructions, whether tumuli, palisade enclosures, or mixed systems,
Philippe Chambon, Aline Thomas
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Boundary Non-Crossing Probabilities as Functionals of the Deterministic Variance Clock

Axioms
We study finite-horizon first-passage time and boundary non-crossing probabilities for Gaussian martingales, viewed as continuous local martingales obtained by running Brownian motion on a deterministic variance clock associated with deterministic ...
Tristan Guillaume
doaj   +1 more source

Oligodendrocyte-derived IL-33 promotes survival to neurotropic flavivirus infection.

, 2023
(A) Ratios of IL-33+ cells in indicated brain regions in adult B6/J mice with HBSS injection. (B) Representative immunofluorescent images of IL-33+ cell loss in B6/J Hippocampal CA3 7 days post intracranial infection with WNV-E218A (20x magnification ...
Steven F. Ziegler (14902049), Andrew Oberst (686925), Joshua M. Ames (17419969), Geoffrey T. Norris (17419966)   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source