Results 151 to 160 of about 9,726 (170)
Design, synthesis and biological evaluation of potent FAAH inhibitors
Bioorganic and Medicinal Chemistry Letters, 2016 International audienceA new series of 3-carboxamido-5-aryl-isoxazoles was designed, synthesized and evaluated for their biological activity. Different pharmacomodulations have been explored and the lipophilicity of these compounds was assessed ...
Regis Millet +2 more
exaly +2 more sources
British Journal of Pharmacology, 2014 Background and Purpose Prostamides are lipid mediators formed by COX-2-catalysed oxidation of the endocannabinoid anandamide and eliciting effects often opposed to those caused by anandamide.
Vincenzo di Marzo +2 more
exaly +2 more sources
Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields [PDF]
European Journal of Medicinal Chemistry, 2009 Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) are the main enzymes responsible for the hydrolysis of endogenous cannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.
Ari Koskinen +2 more
exaly +2 more sources
Arylboronic acids as dual-action FAAH and TRPV1 ligands
Bioorganic and Medicinal Chemistry Letters, 2016 A series of 31 arylboronic acids designed on the basis of the pharmacophore model for a variety of TRPV1 antagonists was prepared and tested on FAAH and TRPV1 channel.
Vincenzo di Marzo +2 more
exaly +2 more sources
ChemMedChem, 2010 FAAH inhibitors: This study identifies a new class of enol carbamates as potent, reversible inhibitors of fatty acid amide hydrolase (FAAH), endowed with high selectivity towards this target over other components of the endocannabinoid ...
Walter Cabri +2 more
exaly +2 more sources
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Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors
Annual Review of Pharmacology and Toxicology, 2021Mario van der Stelt
exaly
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
ACS Medicinal Chemistry Letters, 2011Benjamin Cravatt, Kay Ahn
exaly
Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors
Bioorganic and Medicinal Chemistry Letters, 2011Timothy J Carlson
exaly
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents
European Journal of Medicinal Chemistry, 2020Rati Kailash Prasad Tripathi
exaly