Results 181 to 190 of about 8,951 (213)

Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors

Bioorganic & Medicinal Chemistry Letters, 2009
The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described as promising treatments for pain, anxiety, depression and other CNS-related ...
Fabien, Vincent, Margaret T, Nguyen, Daniel E, Emerling, Michael G, Kelly, Matthew A J, Duncton   +4 more
openaire   +2 more sources

Oxime Carbamate—Discovery of a series of novel FAAH inhibitors

Bioorganic & Medicinal Chemistry Letters, 2010
A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of
S Y, Sit, Charles M, Conway, Kai, Xie, Robert, Bertekap, Clotilde, Bourin, Kevin D, Burris   +5 more
openaire   +2 more sources

Structure based design of novel irreversible FAAH inhibitors

Bioorganic & Medicinal Chemistry Letters, 2009
Fatty acid amide hydrolase (FAAH) has attracted significant attention due to its promise as an analgesic target. This has resulted in the discovery of numerous chemical classes as inhibitors of this potential therapeutic target. In this paper we disclose a new series of novel FAAH irreversible azetidine urea inhibitors.
Jane L, Wang, Scott J, Bowen, Barbara A, Schweitzer, Heather M, Madsen, Joseph, McDonald, Matthew J, Pelc, Ruth E, Tenbrink, David, Beidler, Atli, Thorarensen   +8 more
openaire   +2 more sources

The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms.

British journal of pharmacology, 2014
Anandamide and 2-arachidonoylglycerol are neuromodulatory lipids interacting with cannabinoid receptors, whose availability is regulated by the balance between 'on demand' generation and enzymatic degradation [by fatty acid amide hydrolase (FAAH)/monoacylglycerol lipase].
Barbara, Bosier, Giulio G, Muccioli, Didier M, Lambert   +2 more
openaire   +1 more source

FAAH

2010
Joris C Verster, Thomas M. Tzschentke, Kieran O’Malley, Francis C Colpaert, Bart Ellenbroek, Bart Ellenbroek, R. Hamish McAllister-Williams, Joachim Liepert, Cecilia J. Hillard, Sheldon Preskorn, Megan M Dahmen, Janka Lincoln, Oliver Stiedl, Sven Ove Ögren, E C Warburton, Bernard Le Foll, Mohammed Shoaib, Victoria L Harvey, Tony Dickenson, Ennio Esposito, Roberto William Invernizzi, Ennio Esposito, Robert William Invernizzi, Edoardo Spina, Cyril Höschl, Kim Wolff, Andreas Marneros, Anthony L. Riley, Steve Kohut, Samuel R. Chamberlain, Barbara J. Sahakian, David C.S. Roberts, Joseph Zohar, Seiya Miyamoto, Malcolm Lader, Emma Childs, Lawrence H. Price, Harriet de Wit, Wolfgang Fleischhacker, Lance Richard McMahon, Bernard Le Foll, Bernard Le Foll, Lawrence H. Price, Kieran O’Malley, Kieran O’Malley, Stephen M. Stahl, Meghan M Grady, Stephen C Fowler, Francis C. Colpaert, Alex Hofer, Etienne Sibille, Nicole Edgar, Linda P. Spear, Sam Hutton, Linda Lundstroem, Silvia Gatti McArthur, Will Spooren, Maria Isabel Colado, Richard Green, Marcy J. Bubar, Kathryn A Cunningham, Stephan G. Anagnostaras, Jennifer R Sage, Stephanie A. Carmack, Peter H. Boeijinga, Peter H. Boeijinga, Paul Newhouse, Heather Wilkins, Gary Remington, John Atack, Hilde Lavreysen   +70 more
openaire   +1 more source

Carprofen Derivatives as Inhibitors of FAAH and/or COXs.

2012
Scoperta di molecole strutturalmente correlate a Carprofen in grado di inibire simultaneamente gli enzimi FAAH e COX.
De Vivo M., Scarpelli R., CAVALLI, ANDREA, Favia A., Habrant D., Piomelli D.   +5 more
openaire   +1 more source

A FAAH-fetched approach to treat osteoarthritis pain

Pain, 2011
Aron H, Lichtman, Victoria, Chapman
openaire   +2 more sources

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents

European Journal of Medicinal Chemistry, 2020
Rati Kailash Prasad Tripathi
exaly  

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

ACS Medicinal Chemistry Letters, 2011
Tyzoon K Nomanbhoy, Benjamin F Cravatt, Kay Ahn   +2 more
exaly  

FAAH

2013
openaire   +1 more source