The human factor H protein family – an update [PDF]
Frontiers in ImmunologyComplement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor +13 more
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Complement factor H in molecular regulation of angiogenesis [PDF]
Medical ReviewAngiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang +6 more
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Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H [PDF]
FASEB BioAdvancesThousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries.
Daniele Veggi +13 more
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Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH [PDF]
Frontiers in ImmunologyFactor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B.
Adrián Martín-Ambrosio Doménech +6 more
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Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis [PDF]
BiomedicinesBackground: Membranoproliferative glomerulonephritis (MPGN) is an umbrella term for chronic disorders affecting the glomeruli. MPGN is often accompanied by the presence of autoantibodies against complement components.
Alexandra T. Matola +6 more
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Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]
Frontiers in ImmunologyChagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon +6 more
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Anti-factor H autoantibody-associated hemolytic uremic syndrome in an Argentine pediatric cohort
Exploration of Immunology, 2023 Aim: To describe the clinical characteristics and frequency of anti-factor H (FH) autoantibody-associated atypical hemolytic uremic syndrome (aHUS) in the first cohort of Argentine patients. Methods: The presence of anti-FH autoantibodies in 70 pediatric
Célia Dos Santos +7 more
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Frontiers in Immunology, 2021 C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP.
Ola Kamala +15 more
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The interaction between factor H and Von Willebrand factor. [PDF]
PLoS ONE, 2013 Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS).
Shuju Feng +8 more
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Component factors and binding number conditions in graphs
AIMS Mathematics, 2021 Let $ G $ be a graph. For a set $ \mathcal{H} $ of connected graphs, an $ \mathcal{H} $-factor of a graph $ G $ is a spanning subgraph $ H $ of $ G $ such that every component of $ H $ is isomorphic to a member of $ \mathcal{H} $. A graph $ G $ is called
Sizhong Zhou, Jiang Xu, Lan Xu
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