The interaction between factor H and Von Willebrand factor. [PDF]
PLoS ONE, 2013 Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS).
Shuju Feng +8 more
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Hijacking Factor H for Complement Immune Evasion
Frontiers in Immunology, 2021 The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore +3 more
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Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children [PDF]
Frontiers in Immunology, 2018 Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek +10 more
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Editorial: Function and Dysfunction of Complement Factor H [PDF]
Frontiers in Immunology, 2022 Non peer ...
Mihály Józsi +2 more
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Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces [PDF]
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
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Factor H Family Proteins in Complement Evasion of Microorganisms
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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Factor H Autoantibodies and Membranous Nephropathy
New England Journal of Medicine, 2018 no ...
Claudia Seikrit +2 more
openaire +5 more sources
The human factor H protein family – an update [PDF]
Frontiers in ImmunologyComplement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor +13 more
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Complement factor H in molecular regulation of angiogenesis [PDF]
Medical ReviewAngiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang +6 more
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Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H [PDF]
FASEB BioAdvancesThousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries.
Daniele Veggi +13 more
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