Results 1 to 10 of about 36,394,742 (371)

The interaction between factor H and Von Willebrand factor. [PDF]

PLoS ONE, 2013
Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS).
Shuju Feng, Xiaowen Liang, Miguel A Cruz, Hangoc Vu, Zhou Zhou, Naresh Pemmaraju, Jing-Fei Dong, Michael H Kroll, Vahid Afshar-Kharghan   +8 more
doaj   +6 more sources

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +2 more sources

Factor H Family Proteins in Complement Evasion of Microorganisms

Frontiers in Immunology, 2017
Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
doaj   +2 more sources

The human factor H protein family – an update [PDF]

Frontiers in Immunology
Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor, Noémi Sándor, Andrea E. Schneider, Alexandra T. Matola, Veronika H. Barbai, Dániel Bencze, Hani Hashim Hammad, Alexandra Papp, Dorottya Kövesdi, Dorottya Kövesdi, Barbara Uzonyi, Barbara Uzonyi, Mihály Józsi, Mihály Józsi   +13 more
doaj   +2 more sources

Complement factor H in molecular regulation of angiogenesis [PDF]

Medical Review
Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju   +6 more
doaj   +2 more sources

Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H [PDF]

FASEB BioAdvances
Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries.
Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang, Nicola Pacchiani, Jeannette Sierra, Lynn Chen, Jason Laliberte, Federica Bianchi, Roberta Cozzi, Elisabetta Frigimelica, Domenico Maione, Oretta Finco, Matthew J. Bottomley   +13 more
doaj   +2 more sources

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH [PDF]

Frontiers in Immunology
Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B.
Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero   +6 more
doaj   +2 more sources

Microbes bind complement inhibitor factor H via a common site. [PDF]

PLoS Pathogens, 2013
To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri, H Amdahl, M J Lehtinen, S Hyvärinen, J V McDowell, A Bhattacharjee, S Meri, R Marconi, A Goldman, T S Jokiranta   +9 more
doaj   +2 more sources

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis [PDF]

Biomedicines
Background: Membranoproliferative glomerulonephritis (MPGN) is an umbrella term for chronic disorders affecting the glomeruli. MPGN is often accompanied by the presence of autoantibodies against complement components.
Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi   +6 more
doaj   +2 more sources

Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]

Frontiers in Immunology
Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon, Galia Ramirez-Toloza, Keith L. Wycoff, Sean Ehinger, Jutamas Shaughnessy, Sanjay Ram, Viviana P. Ferreira   +6 more
doaj   +2 more sources