Results 111 to 120 of about 119,277,255 (280)

IGF1R (insulin-like growth factor 1 receptor) [PDF]

, 2009
Review on IGF1R (insulin-like growth factor 1 receptor), with data on DNA, on the protein encoded, and where the gene is ...
Bentov, Y, Werner, H
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein [PDF]

, 2010
Background: The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes.
Wels, Winfried, Pranav Oberoi, Jabulowsky, Robert Alexander, Benhar, Itai, Benjamin Dälken, Oberoi, Pranav, Robert A Jabulowsky, Itai Benhar, Winfried S Wels, Dälken, Benjamin, Dälken Benjamin, Oberoi Pranav, Benhar Itai, Jabulowsky Robert A., Wels Winfried S.   +14 more
core   +1 more source

Antcin-H, a natural triterpene derived from Antrodia cinnamomea, ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome

Journal of Traditional and Complementary Medicine
Inflammatory bowel disease (IBD) comprises idiopathic intestinal disorders, including ulcerative colitis and Crohn's disease. Patients with IBD experience a significantly reduced quality of life, and effective management remains challenging.
Wei-Ting Wong, Lan-Hui Li, Hsiao-Wen Chiu, Mridula P. Menon, Hsien-Ta Hsu, Wen-Yu Lin, Chun-Hsien Wu, Chen-Lung Ho, Kuo-Feng Hua   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule [PDF]

, 2003
Much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite.
Riley, Eleanor M, Sultan, Ali A, J. Brian de Souza, de Souza, J Brian, Eleanor M. Riley, Corran, Patrick H, Patrick H. Corran, Omer, Fakhreldin M, Riley, EM, Sultan, AA, Corran, PH, Ali A. Sultan, Omer, FM, de Souza, JB, Fakhreldin M. Omer   +14 more
core   +1 more source

Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.

PLoS ONE, 2019
Melatonin has protective roles in normal cells and cytotoxic actions in cancer cells, with effects involving autophagy and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factor pathways.
Lucas Sagrillo-Fagundes, Josianne Bienvenue-Pariseault, Cathy Vaillancourt   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells [PDF]

, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival.
Krishnamachary, B., Guus M. Bol, Paul T Winnard, Paul T. Winnard, Vesuna, F., Patel, A.H., Botlagunta, M., Mahendran Botlagunta, Farhad Vesuna, Ramanathan, V., Venu Raman, Arvind H Patel, Arvind H. Patel, Winnard, P.T., Bol, G.M., Guus M Bol, Balaji Krishnamachary   +16 more
core   +1 more source