Results 91 to 100 of about 1,628,545 (288)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Corrigendum: A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Frontiers in Immunology, 2022
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Mihály Józsi, Erik J. M. Toonen, Diana Pauly, Diana Pauly, the SciFiMed consortium   +11 more
doaj   +1 more source

Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells

Journal of Animal Science and Biotechnology, 2017
Background Innate immune responses induced by in vitro stimulation of primary mammary epithelial cells (MEC) using Gram-negative lipopolysaccharide (LPS) and Gram-positive lipoteichoic acid (LTA) bacterial cell wall components are well- characterized in
Omar Bulgari, Xianwen Dong, Alfred L. Roca, Anna M. Caroli, Juan J. Loor   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule [PDF]

, 2003
Much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite.
Riley, Eleanor M, Sultan, Ali A, J. Brian de Souza, de Souza, J Brian, Eleanor M. Riley, Corran, Patrick H, Patrick H. Corran, Omer, Fakhreldin M, Riley, EM, Sultan, AA, Corran, PH, Ali A. Sultan, Omer, FM, de Souza, JB, Fakhreldin M. Omer   +14 more
core   +1 more source

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

Frontiers in Immunology, 2019
Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is characterized by decreased mobility and depressive behavior that occurs in ...
Burak I. Arioz, Bora Tastan, Emre Tarakcioglu, Kemal Ugur Tufekci, Melis Olcum, Nevin Ersoy, Alper Bagriyanik, Alper Bagriyanik, Kursad Genc, Sermin Genc, Sermin Genc   +10 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. [PDF]

, 2012
Krüppel-like factor 8 (KLF8) has only recently been identified to be involved in tumor cell proliferation and invasion of several different tumor entities like renal cell carcinoma, hepatocellular carcinoma and breast cancer.
Schnell, Oliver, Kretzschmar Hans, Juerchott Kathrin, Eigenbrod, Sabina, Valerie Albrecht, Romagna, Alexander, Juerchott, Kathrin, Irene Jaehnert, Jörg-Christian Tonn, Eigenbrod Sabina, Hans Kretzschmar, Jaehnert, Irene, Sabina Eigenbrod (187226), Hans Kretzschmar (187242), Kretzschmar, Hans, Schichor Christian, Romagna, A., Albrecht, Valerie, Christian Schichor, Alexander Romagna, Schnell, O., Juerchott, K., Tonn, Jörg-Christian, Irene Jaehnert (187215), Albrecht, V., Schichor, C., Romagna Alexander, Valerie Albrecht (187218), Eigenbrod, S., Kathrin Juerchott (187233), Christian Schichor (187256), Schichor, Christian, Jörg-Christian Tonn (187250), Albrecht Valerie, Jaehnert, I., Kathrin Juerchott, Kretzschmar, H., Alexander Romagna (187206), Oliver Schnell (187202), Jaehnert Irene, Sabina Eigenbrod, Schnell Oliver, Tonn Jörg-Christian, Tonn, J., Oliver Schnell   +44 more
core   +1 more source

Protective Effect of Nervonic Acid on Oxidative Damage of PC12 Cells Induced by H2O2 [PDF]

Shipin Kexue
This study developed a cell model of oxidative damage by treating PC12 cells for 24 h with 200 µmol/L H2O2 and determined the degree of oxidative stress by assaying the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and lactate
Mayile AIHAITI, LIU Yaojie, LI Jianke
doaj   +1 more source

Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4/MyD88 signaling pathway

Chinese Medicine, 2020
Background Cryptotanshinone (CPT), as a major component of Salvia miltiorrhiza Bunge (Danshen), displays many pharmacological activities including anti-inflammatory effects.
Xin-Xing Li, Xiaoting Zheng, Zhenjie Liu, Qiongming Xu, Hongzhen Tang, Jianfang Feng, Shilin Yang, Chi Teng Vong, Hongwei Gao, Yitao Wang   +9 more
doaj   +1 more source