Results 11 to 20 of about 36,099,759 (329)
Hijacking Factor H for Complement Immune Evasion
Frontiers in Immunology, 2021 The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore +3 more
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Sometimes the impact factor outshines the H index [PDF]
Retrovirology, 2008 Journal impact factor (which reflects a particular journal's quality) and H index (which reflects the number and quality of an author's publications) are two measures of research quality.
Kleber Janet, Hönekopp Johannes
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Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw” [PDF]
Frontiers in Immunology, 2013 Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by ...
Lubna Kouser +5 more
semanticscholar +3 more sources
Factor H Family Proteins in Complement Evasion of Microorganisms
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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Microbes bind complement inhibitor factor H via a common site. [PDF]
PLoS Pathogens, 2013 To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri +9 more
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The Factor H protein family: The switchers of the complement alternative pathway
Immunological Reviews, 2022 The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and ...
Laura Lucientes-Continente +2 more
semanticscholar +1 more source
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
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OncoImmunology, 2020 Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions.
Karolina I. Smolag +8 more
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Human Vaccines & Immunotherapeutics, 2020 Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
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