Results 11 to 20 of about 11,953,655 (218)

Human complement factor H: two factor H proteins are derived from alternatively spliced transcripts [PDF]

European Journal of Immunology, 1991
AbstractThe human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are constitutively expressed in human liver.
Estaller, Cornelia, Schwaeble, Wilhelm, Dierich, Manfred P., Weiss, Elisabeth H.   +3 more
openaire   +6 more sources

Sometimes the impact factor outshines the H index [PDF]

Retrovirology, 2008
Journal impact factor (which reflects a particular journal's quality) and H index (which reflects the number and quality of an author's publications) are two measures of research quality.
Kleber Janet, Hönekopp Johannes
doaj   +6 more sources

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H., Dierich, Manfred P.   +4 more
openaire   +4 more sources

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +1 more source

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Frontiers in Immunology, 2021
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Britta Höchsmann, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt   +10 more
doaj   +1 more source

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Frontiers in Immunology, 2021
Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Mihály Józsi, Erik J. M. Toonen, Diana Pauly, Diana Pauly, the SciFiMed consortium   +11 more
doaj   +1 more source

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

OncoImmunology, 2020
Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions.
Karolina I. Smolag, Christine M. Mueni, Karin Leandersson, Karin Jirström, Catharina Hagerling, Matthias Mörgelin, Paul N. Barlow, Myriam Martin, Anna M. Blom   +8 more
doaj   +1 more source

Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G. [PDF]

Front Immunol
Tschongov T, Konwar S, Kleindienst J, Dabrowska-Schlepp P, Busch A, Schaaf A, Schell C, Rogg M, Häffner K.   +8 more
europepmc   +3 more sources

Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein

Human Vaccines & Immunotherapeutics, 2020
Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
doaj   +1 more source

Factor H Autoantibodies and Complement-Mediated Diseases

Frontiers in Immunology, 2020
Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang, Nicolo Ghiringhelli Borsa, Dingwu Shao, Arthur Dopler, Michael B. Jones, Nicole C. Meyer, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Christoph Q. Schmidt, Richard J. H. Smith   +10 more
doaj   +1 more source