Factor h - Open Access .click

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Factor H autoantibodies in membranoproliferative glomerulonephritis

Molecular Immunology, 2012
Factor H autoantibodies are found in ~10% of aHUS patients. Most are associated with complete deficiency of factor H related proteins 1/3 and bind to the C terminal recognition domain. MPGN, like aHUS, is characterised by complement activation. In this study we, therefore, examined the hypothesis that factor H autoantibodies are associated with MPGN ...
Goodship THJ +18 more
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Complement Factor H: Physiology and Pathophysiology

Seminars in Thrombosis and Hemostasis, 2001
The human plasma protein factor H, which is a multifunctional, multidomain protein, acts as a central regulator of the complement system. In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3 ...
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Complement Factor H