Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration. [PDF]
J NeuroinflammationHector M +6 more
europepmc +1 more source
Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions. [PDF]
, 1991 Christian Timmann +2 more
openalex +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Complement Factor H Y403H Polymorphism in the Turkish Population
Balkan Journal of Medical Genetics, 2010 Yunus Arikan +2 more
doaj +1 more source
Relationship of gene polymorphisms for complement components C3 and factor H and kidney allograft function. [PDF]
BMC NephrolMilinkovic M +8 more
europepmc +1 more source
Colony-Stimulating Factor 1 Expression Is Down-Regulated during the Adipocyte Differentiation of H-1/A Marrow Stromal Cells and Induced by Cachectin/Tumor Necrosis Factor [PDF]
, 1991 Akihiro Umezawa +6 more
openalex +1 more source
Dimerization of complement factor H-related proteins modulates complement activation in vivo
Proceedings of the National Academy of Sciences of the United States of America, 2013 E. Goicoechea de Jorge +10 more
semanticscholar +1 more source