Results 21 to 30 of about 36,394,742 (371)
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
doaj +1 more source
A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
doaj +1 more source
OncoImmunology, 2020 Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions.
Karolina I. Smolag +8 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2020 Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
doaj +1 more source
Factor H Autoantibodies and Complement-Mediated Diseases
Frontiers in Immunology, 2020 Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang +10 more
doaj +1 more source
Definitions, 2020 Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR).
A. Dinasarapu +3 more
semanticscholar +1 more source
Factor H and Neisserial pathogenesis [PDF]
Vaccine, 2008 Both Neisseria gonorrhoeae and N. meningitidis bind to factor H which enhances their ability to evade complement-dependent killing. While porin is the ligand for human fH on gonococci, meningococci use a lipoprotein called factor H binding protein (fHbp) to bind to factor H and enhance their ability to evade complement-dependent killing.
Jo Anne Welsch, Sanjay Ram
openaire +3 more sources
Human complement factor H [PDF]
, 1986 We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Dierich, Manfred P. +4 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2005 Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the formation of drusen, the hallmark lesion of AMD.
semanticscholar +1 more source
Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]
, 1991 The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz +23 more
core +1 more source