Results 21 to 30 of about 28,482,475 (369)
Frontiers in Immunology, 2021 C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP.
Ola Kamala +15 more
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Component factors and binding number conditions in graphs
AIMS Mathematics, 2021 Let $ G $ be a graph. For a set $ \mathcal{H} $ of connected graphs, an $ \mathcal{H} $-factor of a graph $ G $ is a spanning subgraph $ H $ of $ G $ such that every component of $ H $ is isomorphic to a member of $ \mathcal{H} $. A graph $ G $ is called
Sizhong Zhou, Jiang Xu, Lan Xu
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
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OncoImmunology, 2020 Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions.
Karolina I. Smolag +8 more
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Human Vaccines & Immunotherapeutics, 2020 Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
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Factor H and Neisserial pathogenesis [PDF]
Vaccine, 2008 Both Neisseria gonorrhoeae and N. meningitidis bind to factor H which enhances their ability to evade complement-dependent killing. While porin is the ligand for human fH on gonococci, meningococci use a lipoprotein called factor H binding protein (fHbp) to bind to factor H and enhance their ability to evade complement-dependent killing.
Jo Anne Welsch, Sanjay Ram
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Factor H Autoantibodies and Complement-Mediated Diseases
Frontiers in Immunology, 2020 Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang +10 more
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Definitions, 2020 Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR).
A. Dinasarapu +3 more
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Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration
Science, 2005 Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD.
J. Haines +13 more
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Proceedings of the National Academy of Sciences of the United States of America, 2005 Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the formation of drusen, the hallmark lesion of AMD.
semanticscholar +1 more source