Results 21 to 30 of about 28,757,677 (326)

Component factors and binding number conditions in graphs

AIMS Mathematics, 2021
Let $ G $ be a graph. For a set $ \mathcal{H} $ of connected graphs, an $ \mathcal{H} $-factor of a graph $ G $ is a spanning subgraph $ H $ of $ G $ such that every component of $ H $ is isomorphic to a member of $ \mathcal{H} $. A graph $ G $ is called
Sizhong Zhou, Jiang Xu, Lan Xu
doaj   +1 more source

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Frontiers in Immunology, 2021
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Britta Höchsmann, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt   +10 more
doaj   +1 more source

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Frontiers in Immunology, 2021
Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Mihály Józsi, Erik J. M. Toonen, Diana Pauly, Diana Pauly, the SciFiMed consortium   +11 more
doaj   +1 more source

Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu)

Virulence, 2020
Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we
Yanfei Yu, Jia Wang, Rui Han, Li Wang, Lei Zhang, Amy Yimin Zhang, J. Xin, Shao-li Li, Yanhua Zeng, G. Shao, Zhixin Feng, Q. Xiong   +11 more
semanticscholar   +1 more source

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

OncoImmunology, 2020
Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions.
Karolina I. Smolag, Christine M. Mueni, Karin Leandersson, Karin Jirström, Catharina Hagerling, Matthias Mörgelin, Paul N. Barlow, Myriam Martin, Anna M. Blom   +8 more
doaj   +1 more source

Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein

Human Vaccines & Immunotherapeutics, 2020
Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
doaj   +1 more source

Factor H Autoantibodies and Complement-Mediated Diseases

Frontiers in Immunology, 2020
Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang, Nicolo Ghiringhelli Borsa, Dingwu Shao, Arthur Dopler, Michael B. Jones, Nicole C. Meyer, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Christoph Q. Schmidt, Richard J. H. Smith   +10 more
doaj   +1 more source

Factor H and Neisserial pathogenesis [PDF]

Vaccine, 2008
Both Neisseria gonorrhoeae and N. meningitidis bind to factor H which enhances their ability to evade complement-dependent killing. While porin is the ligand for human fH on gonococci, meningococci use a lipoprotein called factor H binding protein (fHbp) to bind to factor H and enhance their ability to evade complement-dependent killing.
Jo Anne Welsch, Sanjay Ram
openaire   +3 more sources

Complement Factor H

Definitions, 2020
Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR).
A. Dinasarapu, A. Chandrasekhar, M. Józsi, S. Subramaniam   +3 more
semanticscholar   +1 more source

Sweeteners for factor H [PDF]

Blood, 2016
In this issue of Blood , [Hyvarinen et al][1][1][2] show that mutant forms of complement factor H, which are commonly associated with atypical hemolytic uremic syndrome (aHUS), have impairments in binding to sialic acid on C3b-coated erythrocytes, platelets, and endothelial cells.
openaire   +3 more sources