Blood, 2016 In this issue of Blood , [Hyvarinen et al][1][1][2] show that mutant forms of complement factor H, which are commonly associated with atypical hemolytic uremic syndrome (aHUS), have impairments in binding to sialic acid on C3b-coated erythrocytes, platelets, and endothelial cells.
openaire +3 more sources
Anti-factor H antibody and its role in atypical hemolytic uremic syndrome
Frontiers in Immunology, 2022 Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An important subset of aHUS is the anti-factor H associated aHUS.
Rupesh Raina +8 more
doaj +1 more source
C3 Glomerulonephritis associated with Anti-complement Factor H Autoantibodies in an Adolescent Male: A Case Report [PDF]
Childhood Kidney Diseases, 2021 C3 glomerulonephritis (C3GN), a rare condition associated with dysregulation of the alternative pathway of the complement system, is histopathologically characterized by isolated or dominant C3 deposition in the renal glomeruli.
HyeSun Hyun +4 more
doaj +1 more source
The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein. [PDF]
PLoS Pathogens, 2012 The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH.
Peter T Beernink +5 more
doaj +1 more source
Journal of Combinatorial Theory, Series B, 1996 The following asymptotic result is proved. For every \(\varepsilon> 0\), and for every positive integer \(h\), there exists an \(n_0= n_0(\varepsilon, h)\) such that for every graph \(H\) with \(h\) vertices and for every \(n> n_0\), any graph \(G\) with \(hn\) vertices and with minimum degree \[ d\geq \Biggl({\chi(H)- 1\over \chi(H)}+ \varepsilon ...
Raphael Yuster, Noga Alon
openaire +2 more sources
Observation of Asymmetric Transport in Structures with Active Nonlinearities [PDF]
, 2013 A mechanism for asymmetric transport based on the interplay between the fundamental symmetries of parity (P) and time (T) with nonlinearity is presented.
Bender, N +6 more
core +3 more sources
Complement factor H in host defense and immune evasion
Cellular and Molecular Life Sciences, 2016 Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity.
Raffaella Parente +3 more
semanticscholar +1 more source
CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]
, 1991 Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P. +4 more
core +2 more sources
Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4
Frontiers in Immunology, 2018 Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on human
Richard B. Pouw +8 more
doaj +1 more source
Supersymmetry and Gravitational Quadrupoles [PDF]
, 1999 We derive model independent, non-perturbative supersymmetric sum rules for the gravitational quadrupole moments of arbitrary-spin particles in any N=1 supersymmetric theory.
Cucchieri +15 more
core +2 more sources