Results 81 to 90 of about 14,184,553 (374)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Signaling mechanisms of the platelet glycoprotein Ib-IX complex

Platelets, 2022
The glycoprotein Ib–IX (GPIb-IX) complex mediates initial platelet adhesion to von Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and transmits VWF binding-induced signals to stimulate platelet activation.
Yaping Zhang, Samuel M Ehrlich, Cheng Zhu, Xiaoping Du   +3 more
doaj   +1 more source

Fragmentation inside an identified jet [PDF]

AIP Conf.Proc.1343:424-426,2011, 2011
Using Soft-Collinear Effective Theory we derive factorization formulae for semi-inclusive processes where a light hadron h fragments from a jet whose invariant mass is measured. Our analysis yields a novel "fragmenting jet function" G_i^h(s,z) that depends on the jet invariant mass \sqrt{s}, and on the fraction z of the large light-cone momentum ...
arxiv   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Purificación del factor IX recombinante expresado en leche de cerdas transgénicas Purification of recombinant factor IX expressed in milk of transgenic sows

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2006
Se purificó a partir de la leche de cerdas transgénicas, factor IX recombinante, y se obtuvieron rendimientos entre 1 a 2 g de esta proteína por litro, lo que resulta una nueva vía para la obtención de este producto con una alta eficiencia, ya que su ...
Armando Cádiz Lahens, Aniel Moya Torres, William Velander, Manuel Limonta Vidal, Lázaro Joo Sánchez, Alexandro Rodríguez Rojas, Laritza Solarana Tito, Alina Díaz Concepción, Patricia Caunedo Almagro, Dunia Castillo González, Delfina Almagro Vázquez   +10 more
doaj  

Scale Factor Dualities in Anisotropic Cosmologies [PDF]

Class.Quant.Grav. 15 (1998) 257-272, 1998
The concept of scale factor duality is considered within the context of the spatially homogeneous, vacuum Brans-Dicke cosmologies. In the Bianchi class A, it is found that duality symmetries exist for the types I, II, VI_0, VII_0, but not for types VIII and IX.
arxiv   +1 more source

Microscopic calculation of the inclusive electron scattering structure function in O-16

, 1999
We calculate the charge form factor and the longitudinal structure function for $^{16}$O and compare with the available experimental data, up to a momentum transfer of 4 fm$^{-1}$.
A. Kievsky, A. Kievsky, B. S. Pudliner, B. S. Pudliner, Bogdan Mihaila, C. R. Chen, D. J. Dean, D. R. Yennie, F. Iachello, H. Kümmel, H. Witala, I. Sick, J. Carlson, J. Carlson, J. E. Amaro, J. H. Heisenberg, Jochen H. Heisenberg, K. M. McVoy, P. Barreau, P. Navratil, R. B. Wiringa, R. Schiavilla, R. Schiavilla, R. Schiavilla, R. Schiavilla, S. C. Pieper, S. Jeschonnek   +26 more
core   +1 more source

Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes [PDF]

, 1991
We have used a recently characterized rabbit antiserum against basic fibroblast growth factor (bFGF), which recognizes various forms of bFGF, to examine the presence and localization of bFGF in the testes of adult rats and mice and the 5-day-old rat.
Gratzl, Manfred, Grothe, C., Mayerhofer, Artur, Rudolf, M., Russell, J. T.   +4 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Homoclinic Chaos in Axisymmetric Bianchi-IX cosmological models with an "ad hoc" quantum potential [PDF]

Phys.Rev.D81:083531,2010, 2010
In this work we study the dynamics of the axisymmetric Bianchi IX cosmological model with a term of quantum potential added. As it is well known this class of Bianchi IX models are homogeneous and anisotropic with two scale factors, $A(t)$ and $B(t)$, derived from the solution of Einstein's equation for General Relativity. The model we use in this work
arxiv   +1 more source