Results 81 to 90 of about 986,336 (320)

Factor V Leiden and Cardiopulmonary Bypass

The Journal of ExtraCorporeal Technology, 2015
We present a case of a patient with factor V Leiden with an antithrombin III activity of 67% who received a successful aortic valve replacement supported by cardiopulmonary bypass (CPB). A safe level of anticoagulation was achieved by monitoring activated clotting time (ACT) and heparin concentration ensuring adequate anticoagulation throughout the ...
Victor, Uppal, Mark, Rosin, Jo-Anne, Marcoux, Marnie, Olson, Jennifer, Bezaire, Gregory, Dalshaug   +5 more
openaire   +2 more sources

Factor V Leiden and Thromboembolism [PDF]

Circulation, 1998
To the Editor: In an excellent study, Ridker et al1 recently demonstrated that the risk of thrombosis is greatly increased when the factor V Leiden mutation and hyperhomocysteinemia, which alone are only moderate risk factors for thrombosis, occur together.
Michael Walter, Holger Reinecke, Günter Breithardt, Gerd Assmann, Jürgen Heinrich   +4 more
openaire   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Prospective Cohort Studies

PLoS Medicine, 2010
Marc Rodger and colleagues report the results of their systematic review and meta-analysis of prospective cohort studies that estimated the association of maternal factor V Leiden and prothrombin gene mutation carrier status and placenta-mediated ...
M. Rodger, M. Betancourt, P. Clark, P. Lindqvist, D. Dizon-Townson, J. Said, U. Seligsohn, M. Carrier, O. Salomon, I. Greer   +9 more
semanticscholar   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Visible‐Light Sensitized Isomerization in the Lipid Bilayer Enables Activation of a Transmembrane Transporter

Angewandte Chemie, EarlyView.
A stiff‐stilbene‐based transmembrane anion transporter is isomerized by energy transfer from a ruthenium tris(bipyridyl) photosensitizer in the lipid bilayer. This sensitized isomerization allows activation of chloride transport using visible instead of UV light, without the need to chemically modify the stiff‐stilbene photoswitch.
Julia Villalva, Abhishek Mondal, Willem Marulanda, Jasper E. Bos, Sylvestre Bonnet, Anjali Pandit, Sander J. Wezenberg   +6 more
wiley   +2 more sources

Prevalencia de factor V Leiden en estudiantes de la Universidad de Talca [PDF]

, 2005
60 p.El organismo consta de muchos sistemas y mecanismos para mantener su equilibrio biológico. Uno de estos mecanismos es el sistema de la hemostasia que esta encargado de evitar o detener la extravasación espontánea o traumática de la sangre hacia los ...
Palomo González, Iván (Prof. Guía), Parra Cifuentes, Daniela   +1 more
core  

Modeled channel distributions explain extracellular recordings from cultured neurons sealed to microelectrodes [PDF]

, 2002
Amplitudes and shapes of extracellular recordings from single neurons cultured on a substrate embedded microelectrode depend not only on the volume conducting properties of the neuron-electrode interface, but might also depend on the distribution of ...
Buitenweg, Jan Reinoud, Marani, Enrico, Rutten, Wim L.C.   +2 more
core   +3 more sources