RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
Experimental Determination of Calcite Solubility in H2O‐KCl‐NaCl‐LiCl Solutions at 700°C and 8 kbar
Geophysical Monograph Series, Page 245-257., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
James Eguchi, Yuan Li, Craig E. Manning
wiley +1 more source
Major Bleeding During Factor Xa Inhibitor Therapy: Lessons from the Pre-Andexanet Era in Japan. [PDF]
J Atheroscler ThrombMinami M.
europepmc +1 more source
Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review
Haemophilia, EarlyView.ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson +2 more
wiley +1 more source
Enoxaparin Dosing and Target anti-Factor Xa Achievement in Infants by Postmenstrual Age. [PDF]
J Pediatr Pharmacol TherPerez D, Mathew K.
europepmc +1 more source
International Journal of Dental Hygiene, EarlyView.ABSTRACT Objectives The aim of this work is to assess and compare the impact of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) during and immediately after periodontal nonsurgical therapy. Materials and Methods A prospective observational cohort study was conducted with patients who presented a history of cardiovascular disease ...
F. Berton +5 more
wiley +1 more source
During pregnancy, anticoagulant effect of low molecular weight heparin can be determined with both thrombelastography and anti-factor Xa activity, or not? [PDF]
Anaesth Intensive CareCarlberg N +3 more
europepmc +1 more source
Does Digitalization Widen Labor Income Inequality?
International Economic Review, EarlyView.ABSTRACT We develop a growth model that endogenizes the occupational choice of workers with different ability levels to study how digitalization affects labor income inequality. The framework incorporates digitalization's multifaceted effects on the economy: (i) it influences economic growth through automation, and (ii) it affects labor income ...
Jilei Huang +3 more
wiley +1 more source
Residue‑resolved dynamically averaged interaction analysis of direct factor Xa inhibitors by MD‑FMO combination calculations. [PDF]
J Comput Aided Mol DesYoshine R +8 more
europepmc +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Bivalirudin is an alternative anticoagulant to heparin and is widely used in pediatric extracorporeal life support (ECLS). Its activity is monitored using activated partial thromboplastin time (aPTT) and/or more specific tests such as plasma‐diluted thrombin time (dTT).
Vadim Kostousov +3 more
wiley +1 more source