Results 101 to 110 of about 644,115 (313)

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]

, 2017
Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J., Meijer, Alexander B., Mertens, Koen, Simpson, Pelle J., van Alphen, Floris P.J., van den Biggelaar, Maartje, van den Eshof, Bart L., Zanivan, Sara   +7 more
core   +2 more sources

Ultrastable One‐Dimensional Ti2S Electride Support for an Efficient and Durable Bifunctional Electrocatalyst

Carbon Energy, EarlyView.
This study reports a stable 1D [Ti2S]2+·2e− electride as robust support for Pt catalysts, exhibiting exceptional HER and ORR activity and durability beyond Pt/C. Its unique dual‐channel anionic electron structure offers insight into electride chemistry, bridging material science and practical energy conversion applications.
Siyuan Ren, Kyoung Ryeol Park, Binod Regmi, Wooseon Choi, Yun Seong Cho, Seon Je Kim, Heechae Choi, Young‐Min Kim, Joohoon Kang, Hyuksu Han, Seong‐Gon Kim, Sung Wng Kim   +11 more
wiley   +1 more source

Enantioselective Desymmetrization by Chiral Bifunctional H‐Bonding Organocatalysts

Chemistry – A European Journal, EarlyView.
Enantioselective desymmetrization has emerged as a highly efficient and conceptually elegant strategy for the construction of chiral molecules from readily available prochiral substrates. This review focuses on recent developments in organocatalytic desymmetrization reactions, with particular emphasis on approaches involving bifunctional activation ...
Michal Urban, Jan Veselý
wiley   +1 more source

Micellar Liquid Chromatography Determination of Edoxaban in Oral Solid Dosage Forms: Theoretical Aspects and Validation

ChemMedChem, EarlyView.
A method is developed and validated to quantify edoxaban in solid oral dosage forms using micellar liquid chromatography. A chemometric strategy is used to study the retention mechanism. The procedure is green, economic, safe, and easy to handle; offers high sample throughput; and is reliable, thus useful for pharmaceutical quality control.
Juan Peris‐Vicente, Devasish Bose, Rajendra‐Pasad Pawar, Abhilasha Durgbanshi, Samuel Carda‐Broch   +4 more
wiley   +1 more source

Role of Physical Therapists in the Management of Individuals at Risk for or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline [PDF]

, 2016
The American Physical Therapy Association (APTA), in conjunction with the Cardiovascular & Pulmonary and Acute Care sections of APTA, have developed this clinical practice guideline to assist physical therapists in their decision-making process when ...
Auten, Beth, Frese, Ethel M., Hillegass, Ellen, Puthoff, Michael, Sobush, Dennis, Thigpen, Mary   +5 more
core   +1 more source

Is there a role for oral triple therapy in patients with acute coronary syndromes without atrial fibrillation? [PDF]

, 2018
© 2018 Bentham Science PublishersBACKGROUND: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term.
Akhtar, Zaki, Farag, Mohamed, Gorog, Diana Adrienne, Spinthakis, Nikolaos   +3 more
core   +2 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Velhos e novos anticoagulantes orais. Perspetiva farmacológica

Revista Portuguesa de Cardiologia, 2012
Resumo: A terapêutica anticoagulante oral está em mudança. A varfarina e o acenocumarol constituem ainda o padrão anticoagulante oral em muitos contextos clínicos.
Pedro Marques da Silva
doaj   +1 more source

The ISFET based heparin sensor with a monolayer of protamine as affinity ligand [PDF]

, 1995
The ion-step measuring method was used to determine absolute heparin concentrations in PBS and blood plasma with a Ta2O5 ISFET on to which a monolayer of protamine had been immobilized. Heparin is a highly negatively charged polysaccharide, which is used
Bergveld, P., Kerkhof, J.C. van, Schasfoort, R.B.M.   +2 more
core   +2 more sources

Randomized investigation of heart failure therapy in patients with advanced cancer at risk of cardiac wasting: Rationale and design of the EMPATICC trial

European Journal of Heart Failure, EarlyView.
EMPower the heArt of patients with TermInal Cancer using Cardiac medicines (EMPATICC). eGFR, estomated glomerular filtration rate; EP, endpoint; FCM, ferric carboxymaltose; LVEF, left ventricular ejection fraction; N‐terminal pro‐B‐type natriuretic peptide; PGA, patient global assessment; PoC, proof of concept; QoL, quality of life; UICC, Union for ...
Markus S. Anker, Amir A. Mahabadi, Matthias Totzeck, Mitra Tewes, Raluca Mincu, Muhammad Shahzeb Khan, Javed Butler, Ulrich Keller, Johann Ahn, Lars Bullinger, Dominik P. Modest, Ulf Landmesser, Lorenz H. Lehmann, Sven Bercker, Ulrich Laufs, Michael Böhm, Bela Merkely, Monika Diek, Tim Heise, Martin Hellmich, Marius Placzek, Tim Friede, Stefan D. Anker, Tienush Rassaf   +23 more
wiley   +1 more source