Results 131 to 140 of about 655,147 (306)

Deep vein thrombosis prophylaxis in patients who undergo knee arthroscopy: a systematic review

Knee Surgery & Related Research
Background Knee arthroscopy is one of the most common procedures performed by orthopedic surgeons. A potentially life-threatening complication following this procedure is deep vein thrombosis (DVT). DVT prophylaxis can be obtained both mechanically (e.g.,
Udit Dave, Emma G. Lewis, Victoria K. Ierulli, Shreya M. Saraf, Mary K. Mulcahey   +4 more
doaj   +1 more source

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Immunology, EarlyView.
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat, Priyanka Khatri, Youssif M. Ali, Chanuka H. Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L. Miners, Kristin Ladell, Samantha A. Jones, Helen E. Davies, David A. Price, Wioleta M. Zelek, B. Paul Morgan, Wilhelm J. Schwaeble, Nicholas J. Lynch   +14 more
wiley   +1 more source

Changes in Internal Structure and Dynamics upon Binding Stabilise the Nematode Anticoagulant NAPc2

Biomolecules
Abnormal blood coagulation is a major health problem and natural anticoagulants from blood-feeding organisms have been investigated as novel therapeutics.
Elaine Woodward, Brendan M. Duggan
doaj   +1 more source

Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series

Journal of Medical Case Reports, 2018
Background The lack of an antidote against factor Xa inhibitors in case of major bleeding or need for urgent surgery is a concern to clinicians. Guidelines on managing major bleeding in patients under anticoagulation with a factor Xa inhibitor suggest ...
Nina Haagenrud Schultz, Runar Lundblad, Pål Andre Holme   +2 more
doaj   +1 more source

Betrixaban – the next direct factor Xa inhibitor?

Expert Review of Hematology, 2016
Venous thromboembolism is a major global health burden. Since the 1930s, prevention of stroke and pulmonary embolism in these patients has been achieved using conventional anticoagulants, such as heparin and warfarin. However, in recent years, four direct non-vitamin K antagonist oral anticoagulants (DOACs) have entered the market as alternative ...
Thoenes, Martin, Minguet, Joan, Bramlage, Karin, Bramlage, Peter, Ferrero Rodríguez, Carmen   +4 more
openaire   +4 more sources

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

INVESTIGATION OF ANTICOAGULATION PROPERTIES OF SULFATED GLYCOSAMINOGLYCAN MIMETICS [PDF]

, 2017
INVESTEGATION OF ANTICOAGULATION PROPERTIES OF SULFATED GLYCOSAMINOGLYCAN MIMETICS By Elsamani Ismail Abdelfadiel, MS A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University ...
Abdelfadiel, Elsamani I
core   +1 more source

Four-factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors versus Warfarin in Life-threatening Bleeding [PDF]

, 2021
Megan A. Rech, Dalila Masic, Drayton A. Hammond   +2 more
openalex   +1 more source

Mercy Consent and Contained Resistance: Grievance Systems in Chinese Food‐Delivery Platforms

New Technology, Work and Employment, EarlyView.
ABSTRACT Based on a multi‐methods qualitative study, this article investigates how in‐platform grievance systems operate in the Chinese food‐delivery platform work. Drawing on labour process theory, we examine the role of in‐platform grievance systems in shaping the dynamic interplay between control, consent, and resistance. Our findings reveal that in‐
Ziheng Liu, Wei Wei
wiley   +1 more source

POSSIBILITIES OF INHIBITING ANTICOAGULANT ACTIVITIES THAT INHIBIT XA-FACTOR

Атеротромбоз, 2019
The article deals with the possibility of suppressing the effect of drugs inhibiting the activity of the Xa-Factor of the clotting blood system. Wide indications for oral anticoagulants are atrial fibrillation, venous thrombosis, thromboembolism, etc ...
A. D. Erlich
doaj   +1 more source