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Factor XI and XIa inhibition: a new approach to anticoagulant therapy. [PDF]
Br J CardiolSammut MA, Elamin N, Storey RF.
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Targeting factor XI and factor XIa to prevent thrombosis.
BloodGailani D, Gruber A.
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Seminars in Thrombosis and Hemostasis, 2009
Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. In the past two decades, more than 180 mutations in the FXI gene have been reported in patients with FXI deficiency, five of which show a founder effect (Cys38Arg, Gln88Stop, Cys128Stop, Glu117stop, and Phe283Leu, the last two largely ...
S. Duga, O. Salomon
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Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. In the past two decades, more than 180 mutations in the FXI gene have been reported in patients with FXI deficiency, five of which show a founder effect (Cys38Arg, Gln88Stop, Cys128Stop, Glu117stop, and Phe283Leu, the last two largely ...
S. Duga, O. Salomon
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Haemophilia, 2008
Summary. Although factor XI (FXI) deficiency has a particularly high incidence in Ashkenazi Jews, it is now frequently diagnosed in other ethnic groups. This review gives an overview of the basic pathophysiology, clinical manifestations, and management of FXI deficiency.
K, Gomez, P, Bolton-Maggs
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Summary. Although factor XI (FXI) deficiency has a particularly high incidence in Ashkenazi Jews, it is now frequently diagnosed in other ethnic groups. This review gives an overview of the basic pathophysiology, clinical manifestations, and management of FXI deficiency.
K, Gomez, P, Bolton-Maggs
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Inhibitors to Factor XI in Patients With Severe Factor XI Deficiency
Seminars in Hematology, 2006Factor XI (FXI) deficiency is a rare bleeding disorder that may arise from any of a number of missense, nonsense, splice site, insertion, and deletion mutations within the FXI gene. Severely affected patients are at considerable risk of developing inhibitors to FXI and, although spontaneous bleeding is uncommon in such patients, bleeding after surgery ...
Ophira, Salomon +3 more
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JAMA: The Journal of the American Medical Association, 1977
To the Editor.— The article by Jokl and Federico entitled "Myositis Ossificans Traumatica: Association with Hemophilia (Factor XI Deficiency) in a Football Player" (237:2215-2216, 1977) is not adequately documented as a case of factor XI deficiency. Factor XI assays in their patient were determined to be 46% and 52%.
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To the Editor.— The article by Jokl and Federico entitled "Myositis Ossificans Traumatica: Association with Hemophilia (Factor XI Deficiency) in a Football Player" (237:2215-2216, 1977) is not adequately documented as a case of factor XI deficiency. Factor XI assays in their patient were determined to be 46% and 52%.
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Contact Activation of Factor XI
British Journal of Haematology, 1981Summary. Factor XI is a circulating trace plasma protein composed of two similar or identical chains of about 80 000 daltons which upon activation undergo proteolytic cleavage. Recently, we have shown that trypsin activation leads to an active factor XI (factor XIa) which, on reduction, yields three chains of 46 000, 37 000 and 26 000 daltons.
A, Jacobs +3 more
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The management of factor XI deficiency
Haemophilia, 1998Summary. Factor XI deficiency leads to a more variable bleeding tendency than haemophilia A or B. Although severely deficient individuals are likely to bleed excessively especially after surgery in areas of the body with increased fibrinolysis, there is evidence that some partially deficient individuals are at risk of excessive bleeding.
C. A. Lee +5 more
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Factor XI gene mutations in factor XI deficient patients of the Czech Republic
American Journal of Hematology, 2008AbstractFactor XI (FXI) deficiency is an autosomal inherited coagulation disorder characterized by bleeding symptoms mainly associated with injury or surgery. Although most of the FXI gene mutations in Ashkenazi Jews are represented by the Glu117stop or Phe283Leu mutations, considerable genetic heterogeneity has been reported in other populations.
G. Castaman +5 more
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