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Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency

Blood Coagulation & Fibrinolysis, 2005
Hereditary factor XI deficiency is a rare bleeding disorder that is found worldwide. Rapidly increasing numbers of mutations and polymorphisms in various populations have been reported. However, the number of identified mutations given in recent literature and available databases is named to be not more than 35.
Astrid, Dossenbach-Glaninger   +1 more
openaire   +2 more sources

Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain

Blood, 2004
AbstractThe bleeding diathesis associated with hereditary factor XI (fXI) deficiency is prevalent in Ashkenazi Jews, in whom the disorder appears to be an autosomal recessive condition. The homodimeric structure of fXI implies that the product of a single mutant allele could confer disease in a dominant manner through formation of heterodimers with ...
Kravtsov, Dmitri V.   +7 more
openaire   +3 more sources

Prostatectomy in Factor XI Deficiency

Journal of Urology, 1977
Factor XI deficiency, an uncommon inherited coagulopathy characterized by an absence of bleeding history but bleeding after an operation or trauma, has not been reported previously in urologic patients. The diagnosis is made by a specific factor assay after an abnormal partial thromboplastin time and the treatment is fresh frozen plasma.
openaire   +2 more sources

Acquired Factor XI Inhibitors in Two Patients with Hereditary Factor XI Deficiency

Thrombosis and Haemostasis, 1984
SummaryTwo patients with hereditary factor XI deficiency developed inhibitors following plasma transfusions. Neither had severe spontaneous bleeding. The patients’ plasmas neutralized both factor XI in plasma, purified factor XI, and purified factor XIa. The inhibitor in both patients’ plasmas adsorbed to Protein A- Sepharose.
K, Morgan, S, Schiffman, D, Feinstein
openaire   +2 more sources

The Relation of ‘Fletcher Factor’ to Factors XI and XII

British Journal of Haematology, 1970
Summary. Further evidence is presented for the existence of a new coagulation factor which is closely related to Hageman factor (XII) and plasma thromboplastin antecedent, PTA (XI). This factor has been tentatively designated ‘Fletcher factor’. Coagulant activity of Fletcher factor was separated from the clotting activity of factors XI and XII by C‐M ...
W E, Hathaway, J, Alsever
openaire   +2 more sources

Historical perspective of factor XI

Thrombosis Research, 2005
Discovery and contact activation . . . . . . . . . . . . . . . . . . . . . . . . . . 441 Purification and characterization . . . . . . . . . . . . . . . . . . . . . . . . . . 442 Primary structure and bappleQ domain . . . . . . . . . . . . . . . . . . . . . . . 443 Platelet factor XI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire   +2 more sources

Factor XI

Reactions Weekly, 2015
openaire   +2 more sources

Factor-XI

Reactions Weekly, 2020
openaire   +1 more source

Interaction of factor XI and sulfatide

Thrombosis Research, 1986
S, Schiffman, R, Rosenfeld, A D, Retzios
openaire   +2 more sources

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