Results 81 to 90 of about 9,160 (266)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
On matrices associated to prime factorization of odd integers
Condensed Matter Physics, 2008 In this paper we introduce in section 5 integral matrices M(n) for any factorization of an odd integer n into r distinct odd primes. The matrices appear in several versions according to a parameter ρ∈[0,1], they have size 2r×2r and their rank satisfies e.
T. Bier
doaj +1 more source
OCMA: Fast, Memory-Efficient Factorization of Prohibitively Large Relationship Matrices
G3: Genes, Genomes, Genetics, 2019 Matrices representing genetic relatedness among individuals (i.e., Genomic Relationship Matrices, GRMs) play a central role in genetic analysis. The eigen-decomposition of GRMs (or its alternative that generates fewer top singular values using genotype ...
Zhi Xiong +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Effective Temporal Graph Learning via Personalized PageRank
EntropyGraph representation learning aims to map nodes or edges within a graph using low-dimensional vectors, while preserving as much topological information as possible.
Ziyu Liao, Tao Liu, Yue He, Longlong Lin
doaj +1 more source
Abstract and Applied Analysis, 2014 Circulant matrices play an important role in solving ordinary and partial differential equations. In this paper, by using the inverse factorization of polynomial of degree n, the explicit determinants of circulant and left circulant matrix involving ...
Juan Li, Zhaolin Jiang, Fuliang Lu
doaj +1 more source
Factorizations of operator matrices
Linear Algebra and its Applications, 1995 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source