Experimental Study and Failure Criterion Analysis on Combined Compression-Shear Performance of Self-Compacting Concrete. [PDF]
Materials (Basel), 2020 Jingrong W +3 more
europepmc +1 more source
Evaluation of closed cubic failure criterion for graphite/epoxy laminates [PDF]
An analytical method has been developed to ensure closure of the cubic form of the tensor polynomial strength criterion. The intrinsic complexity of the cubic function is such that special conditions must be met to close the failure surface in three ...
Jiang, Zhiqing, Tennyson, R. C.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nonlinear response and failure characteristics of internally pressurized composite cylindrical panels [PDF]
Results of an experimental and analytical study of the nonlinear response and failure characteristics of internally pressurized 4- to 16-ply-thick graphite-epoxy cylindrical panels are presented.
Boitnott, R. L. +2 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
ANISAP: A three-dimensional finite element program for laminated composites subjected to mechanical loading [PDF]
ANISAP is a 3-D finite element FORTRAN 77 computer code for linear elastic, small strain, analysis of laminated composites with arbitrary geometry including free edges and holes.
Burns, S. W. +2 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Postbuckling delamination of a stiffened composite panel using finite element methods [PDF]
A combined numerical and experimental study is carried out for the postbuckling behavior of a stiffened composite panel. The panel is rectangular and is subjected to static in-plane compression on two opposite edges to the collapse level.
Babcock, C. D. +2 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Nonlinear temperature dependent failure analysis of finite width composite laminates [PDF]
A quasi-three dimensional, nonlinear elastic finite element stress analysis of finite width composite laminates including curing stresses is presented. Cross-ply, angle-ply, and two quasi-isotropic graphite/epoxy laminates are studied.
Herakovich, C. T., Nagarkar, A. P.
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