Results 101 to 110 of about 8,216,509 (304)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A New Approach to Electrical Fault Detection in Urban Structures Using Dynamic Programming and Optimized Support Vector Machines

Sensors
Electrical power systems are crucial, yet vulnerable, due to their complex and interconnected nature, necessitating effective fault detection and diagnostics to ensure stability and prevent disruptions.
Reynaldo Villarreal, Sindy Chamorro-Solano, Yolanda Vega-Sampayo, Carlos Alejandro Espejo, Steffen Cantillo, Luis Gaviria, Jheifer Paez, Carlos Ochoa, Silvia Moreno, Claudet Polo, Roberto Pestana-Nobles, Camilo Montoya   +11 more
doaj   +1 more source

Improvements of a Failure Database for Marine Diesel Engines Using the RCM and Simulations

Energies, 2019
Diesel engines are widely used in marine transportation as a direct connection to the propeller and as electrical principal or auxiliary generator sets. The engine is the most critical piece of equipment on a vessel platform; therefore, the engine’ ...
Francisco Vera-García, José Antonio Pagán Rubio, José Hernández Grau, Daniel Albaladejo Hernández   +3 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Study on Fault-tolerant Control Measures of Hybrid Power System for Tramcar

机车电传动, 2016
Frequent failures of hybrid power system and corresponding fault-tolerant control measures which ensured the tramcarrunning safety and reliability was studied, and an effective scheme to improve the power performance, security and reliability of ...
LI Ming, SHI Junjie, WANG Xinghua
doaj  

Detecting Data Integrity Failures [PDF]

, 1997
All data in systems will contain integrity failures (errors). Their causes are legion and endemic. Their effect is random and sometimes disastrous. This paper sets out a basic theory of how these errors can be managed in a secure system. In summary the theory requires that processing and reporting programs contain error detection functionality and that
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Integrating Time Interval Petri Nets with fuzzy logic for enhanced failure monitoring and detection

Cogent Engineering
This research introduces a novel approach to fault detection and diagnosis by integrating Fuzzy Logic with Time Interval Petri Nets (TIPNs) to generate Fuzzy Interval Petri Nets (FIPNs). The method offers a robust and adaptable solution for detecting and
Fatma Lajmi, Wiem Abdelbaki
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Towards a High Reliable Enforcement of Safety Regulations - A Workflow Meta Data Model and Probabilistic Failure Management Approach

Transactions on Environment and Electrical Engineering, 2016
Today’s companies are able to automate the enforcement of Environmental, Health and Safety (EH&S) duties through the use of workflow management technology.
Heiko Henning Thimm
doaj   +1 more source