Results 101 to 110 of about 52,035 (209)

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK [PDF]

, 2008
Focal adhesion kinase (FAK) plays a critical role during vascular development because knockout of FAK in endothelial cells (ECs) is embryonic lethal.
Tang-Long Shen, Cheresh, David A, Jun-Lin Guan, Guan, Jun-Lin, Sara M. Weis, Chen, Xiao Lei, Shen, Tang-Long, Lutu-Fuga, Kimberly M, Weis, SM; Lim, S-T; Lutu-Fuga, KM; Barnes, LA; Chen, X.L.; Gothert, J.R.; Shen, T-L; Guan, J-L; Schlaepfer, DD; Cheresh, DA, David A. Cheresh, Barnes, Leo A, Xiao Lei Chen, Göthert, Joachim R, Ssang-Taek Lim, Schlaepfer, David D, Leo A. Barnes, Joachim R. Göthert, David D. Schlaepfer, Weis, Sara M, Kimberly M. Lutu-Fuga, Lim, Ssang-Taek   +20 more
core   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

FAK PRR2 or FAK PRR3 regions are needed to promote transient cortactin co-localization with FAK at FAs.

, 2012
FAK−/− or the indicated GFP-FAK reconstituted MEFs were serum starved, held in suspension, FN replated for 60 min, and then analyzed for endogenous paxillin (green) or cortactin (red) immuno-staining.
Alok Tomar (139282), Christine Lawson (139286), Majid Ghassemian (139287), David D. Schlaepfer (139290)   +3 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

FAK regulates cardiomyocyte survival following ischemia/reperfusion [PDF]

, 2009
Myocyte apoptosis is central to myocardial dysfunction following ischemia/reperfusion (I/R) and during the transition from hypertrophy to heart failure.
Hakim, Zeenat, Taylor, Joan, Meredith, Dane, DiMichele, Laura, Rojas, Mauricio, Mack, Christopher   +5 more
core   +1 more source

Exosome‐mimetic vesicle‐encapsulated multi‐responsive antibacterial hydrogel core‐shell microneedle patch promotes scarless healing of infected wounds

BMEMat, EarlyView.
The core‐shell microneedle patch VP@FNV‐CuO2‐MN was fabricated by encapsulating n‐CuO2 in a moderately crosslinked PVA/CMCS/Borax4 hydrogel shell and VP‐loaded fibroblast membrane nanovesicles (VP@FNV) in a highly crosslinked PVA/CMCS/Borax6 hydrogel core. Upon application to an infected wound, the acidic microenvironment triggers Fenton‐like reactions
Ziwei Jiang, Huihui Zhang, Lianglong Chen, Zhangfeifan Yang, Sai Cao, Yufang He, Xiaoyang Liu, Siew Yee Wong, Xu Li, Hai Zhou, Ziyan Li, Zijun Zheng, Lei Yang   +12 more
wiley   +1 more source

Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice

Neurobiology of Stress
Astrocytes have been implicated in stress responses and produce ciliary neurotrophic factor (CNTF), which we have shown in the mouse medial amygdala (MeA) to promote passive stress coping response only in females.
Cuihong Jia, W. Drew Gill, Chiharu Lovins, Russell W. Brown, Theo Hagg   +4 more
doaj   +1 more source

Viscoelastic hydrogel potentiates cancer cell stemness and drug resistance through Piezo1‐dependent mechanotransduction

BMEMat, EarlyView.
The effects of matrix dynamics on cancer progression remain unclear. Herein, we fabricated a tunable dynamic hydrogel via reversible host–guest crosslinking and demonstrated that high matrix dynamics activate Piezo1 and its downstream PI3K/AKT and Wnt/β‐catenin signaling pathways, thereby enhancing cancer spheroid assembly, elevating cancer stemness ...
Yi Liu, Huiyao Deng, Hanlei Zhang, Chutian Huang, Huolun Feng, Xiayi Xu, Heemin Kang, Meiling Zhu, Liming Bian, Kunyu Zhang   +9 more
wiley   +1 more source

Adipocyte‐specific FAK deletion promotes pancreatic β‐cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus

Clinical and Translational Medicine
Background White adipose tissue (WAT) has a key role in maintaining energy balance throughout the body, and their dysfunction take part in the regulation of diabetes mellitus.
Fei Ding, Peng Zheng, Hong‐Ting Fang, Yuan‐Yuan Luo, Xi‐Yue Yan, Hui‐Jian Chen, You‐E Yan   +6 more
doaj   +1 more source