Results 91 to 100 of about 52,035 (209)
, 2014 (A) Fluorescence images taken at the base of fixed cells expressing wild-type or mutant GFP-FAK and mCherry-SrcY530F and immunostained for cortactin (upper panel) or paxillin (lower panel).
Ken Takeda (441984) +6 more
core +1 more source
From Interferon Signature to the Clinical Landscape: Type I Interferonopathies
Arthritis &Rheumatology, EarlyView.Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz +13 more
wiley +1 more source
FAK-Del33 is phosphorylated due to enhanced auto-phosphorylation.
, 2014 MDA-MB-468 cells were transfected with 2 µg of plasmids encoding FAK-Del33, FAK-Del33/Y397F, FAK-WT, and FAK-WT/Y397F in 6-well plates. The total amount of DNA was kept constant by the addition of empty vector.
Xiangfan Liu (294313) +7 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić +4 more
wiley +1 more source
Regulation of FAK and cortactin binding by FN adhesion.
, 2012 (A) Lysates were made from MEFs held in suspension for 30 min or FN re-plated (30 and 60 min) and were analyzed by cortactin or FAK antibody immunoprecipitation (IP) followed by immunoblotting for cortactin and FAK.
Alok Tomar (139282) +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić +8 more
wiley +1 more source
, 2013 (A) FAK activation was determined by Grb2/FAK co-immunoprecipitation reactions on Ad-FAK reconstituted FAK−/− cells infected with Ad-US28 that were treated with RANTES, Fractalkine, MCP-1. Cells were harvested in modified RIPA buffer at 0 (unstimulated),
Laurel Hall (374433) +10 more
core +1 more source
Interactions that contribute to FAK activation [PDF]
, 2006 Focal adhesion kinase (FAK) is an important regulatory protein that integrates signals from integrins and growth factor receptors to control cell growth, survival, and migration.
Scheswohl, Danielle Marie
core +1 more source
Economic evaluations of antiobesity medications: A systematic literature review
British Journal of Clinical Pharmacology, EarlyView.The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković +5 more
wiley +1 more source
PLoS ONE, 2015 Cancer cell motility is a key phenomenon regulating invasion and metastasis. Focal adhesion kinase (FAK) plays a major role in cellular adhesion and metastasis of various cancers.
Pasupathi Sundaramoorthy +10 more
doaj +1 more source